Sunil Shaunak

TL;DR: Phylogenetic analyses indicated that substitutions emerged under natural selection rather than by genetic drift or linkage for outgrowth of CTL escape viruses required high viral loads and additional, possibly compensatory, mutations in the gag protein.

TL;DR: It is demonstrated here ongoing virus replication in a large percentage of infected individuals on highly active anti-retroviral therapy, despite sustained undetectable levels of plasma viral RNA, has important implications for the clinical management of HIV-1-infected individuals and for the development of virus eradication strategies.

TL;DR: It is concluded that synthetically engineered macromolecules such as the dendrimers described here can be tailored to have defined immuno-modulatory and antiangiogenic properties, and they can be used synergistically to prevent scar tissue formation.

TL;DR: It is shown that native disulfides in human interferon α-2b and in a fragment of an antibody to CD4+ can be modified by site-specific bisalkylation of the two cysteine sulfur atoms to form a three-carbon PEGylated bridge.

TL;DR: The studies suggest that peptides, proteins, enzymes, and antibody fragments can be site-specifically PEGylated across a native disulfide bond using three-carbon bridges without destroying their tertiary structure or abolishing their biological activity.