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Ian O. Ellis
Researcher at University of Nottingham
Publications - 1071
Citations - 84964
Ian O. Ellis is an academic researcher from University of Nottingham. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 126, co-authored 1051 publications receiving 75435 citations. Previous affiliations of Ian O. Ellis include Mansoura University & Curie Institute.
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Loss of expression of chromosome 16q genes DPEP1 and CTCF in lobular carcinoma in situ of the breast
Andrew R. Green,Sophie Krivinskas,Peter Young,Emad A. Rakha,E. Claire Paish,Desmond G. Powe,Ian O. Ellis +6 more
TL;DR: Loss of CTCF and DPEP1 gene expression suggest they are possible TSG in breast cancer and may, similar to CDH1, be potentially utilised as markers of predisposition of women diagnosed with LCIS.
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Heregulin β1 drives gefitinib-resistant growth and invasion in tamoxifen-resistant MCF-7 breast cancer cells
Iain Robert Hutcheson,Janice Mary Knowlden,Stephen Edward Hiscox,Denise Barrow,Julia Margaret Wendy Gee,John F.R. Robertson,Ian O. Ellis,Robert Ian Nicholson +7 more
TL;DR: HRGβ1 can overcome the inhibitory effects of gefitinib on cell growth and invasion in Tam-R cells through promotion of erbB3/erbB2 heterodimerization and activation of the phosphatidylinositol 3-kinase/AKT signalling pathway.
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Clinicopathological significance of KU70/KU80, a key DNA damage repair protein in breast cancer
Alaa T. Alshareeda,Alaa T. Alshareeda,Ola H. Negm,Ola H. Negm,Nada Albarakati,Andrew R. Green,Christopher C. Nolan,Rebeka Sultana,Srinivasan Madhusudan,Ahmed Benhasouna,Paddy Tighe,Ian O. Ellis,Emad A. Rakha +12 more
TL;DR: KU70/KU80 may play a role in DNA DSBs repair in HR-deficient tumours in sporadic BC and show an association with disease-free interval; however, it was not an independent predictor of outcome.
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Analysis of short stature homeobox-containing gene ( SHOX) and auxological phenotype in dyschondrosteosis and isolated Madelung deformity.
Giedre Grigelioniene,Jacqueline Schoumans,Lo Neumeyer,Sten A. Ivarsson,Ole Eklöf,Ove Enkvist,Paul Tordai,Inger Fosdal,Anne Grethe Myhre,Otto Westphal,Nils Östen Nilsson,Maria Elfving,Ian O. Ellis,Britt-Marie Anderlid,Ingegerd Fransson,Isabel Tapia-Páez,Magnus Nordenskjöld,Lars Hagenäs,Jan P. Dumanski +18 more
TL;DR: It is concluded that mutations in the SHOX gene are the major factor in the pathogenesis of Dyschondrosteosis.
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Clinicopathologic and molecular significance of phospho-Akt expression in early invasive breast cancer
Mohammed A. Aleskandarany,Emad A. Rakha,Mohamed A. H. Ahmed,Mohamed A. H. Ahmed,Desmond G. Powe,Ian O. Ellis,Ian O. Ellis,Andrew R. Green +7 more
TL;DR: Combinatorial phenotypic groups of PIK3CA/pAkt denoted functional complexity, at translational level, within the upstream and downstream arms of Akt activation with significant impact on patients’ outcome.