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Igor Baburin
Researcher at University of Vienna
Publications - 35
Citations - 1377
Igor Baburin is an academic researcher from University of Vienna. The author has contributed to research in topics: GABAA receptor & Receptor. The author has an hindex of 18, co-authored 34 publications receiving 1210 citations.
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Artemisinins Target GABAA Receptor Signaling and Impair α Cell Identity
Jin Li,Tamara Casteels,Thomas Frogne,Camilla Ingvorsen,Christian Honoré,Monica Courtney,Kilian Huber,Nicole Schmitner,Robin A. Kimmel,Roman A. Romanov,Roman A. Romanov,Caterina Sturtzel,Charles-Hugues Lardeau,Johanna Klughammer,Matthias Farlik,Sara Sdelci,Andhira Vieira,Fabio Avolio,François Briand,Igor Baburin,Peter Májek,Florian M. Pauler,Thomas Penz,Alexey Stukalov,Manuela Gridling,Katja Parapatics,Charlotte Barbieux,Ekaterine Berishvili,Ekaterine Berishvili,Andreas Spittler,Jacques Colinge,Keiryn L. Bennett,Steffen Hering,Thierry Sulpice,Christoph Bock,Christoph Bock,Christoph Bock,Martin Distel,Tibor Harkany,Tibor Harkany,Dirk Meyer,Giulio Superti-Furga,Giulio Superti-Furga,Patrick Collombat,Jacob Hecksher-Sørensen,Stefan Kubicek +45 more
TL;DR: It is shown that the protein gephyrin is the mammalian target of these antimalarial drugs and that the mechanism of action of these molecules depends on the enhancement of GABAA receptor signaling.
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Valerenic acid potentiates and inhibits GABA A receptors: Molecular mechanism and subunit specificity
Sophia Khom,Igor Baburin,Eugen Timin,Annette Hohaus,Gabriele Trauner,Brigitte Kopp,Steffen Hering +6 more
TL;DR: VA was identified as a subunit specific allosteric modulator of GABA(A) receptors that is likely to interact with the loreclezole binding pocket and shifted the GABA concentration-effect curve towards lower GABA concentrations and elicited substantial currents through GABA( A) channels at > or = 30 microM.
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Pharmacological Properties of GABAA Receptors Containing γ1 Subunits
TL;DR: In this article, the authors expressed alpha(1)beta(2)gamma(1)-GABA(A) receptors in Xenopus laevis oocytes and analyzed their modulation by 21 ligands from 12 structural classes making use of the two-microelectrode voltage-clamp method and a fast perfusion system.
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Modulation of GABAA Receptors by Valerian Extracts is Related to the Content of Valerenic Acid
TL;DR: The data show that the extent of GABAA receptor modulation by Valerian extracts is related to the content of valerenic acid.
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Automated fast perfusion of Xenopus oocytes for drug screening
TL;DR: A method for automated fast perfusion of neurotransmitters (or drugs) during two-microelectrode voltage-clamp experiments on Xenopus oocytes is described, suitable for screening studies on ligand- and voltage-gated ion channels.