Ilana Buchumenski

TL;DR: The induction of sufficient inflammation in tumours that are sensitized to interferon can bypass the therapeutic requirement for CD8+ T cell recognition of cancer cells and may provide a general strategy to overcome immunotherapy resistance.

TL;DR: It is shown that A-to-I editing and the enzymes mediating this modification are significantly altered, usually elevated, in most cancer types, and increased editing activity is found to be associated with patient survival.

TL;DR: It is demonstrated that targeting ADAR1 represents a potential therapeutic vulnerability in cancers with activated interferon response signatures, suggesting that both catalytic and non-enzymatic functions of ADar1 may contribute to preventing PKR-mediated cell lethality.

TL;DR: The important effect of RNA editing on miRNA-regulation in the tumor cell is established, with prospects for diagnostic and prognostic applications.

TL;DR: The data shows that ADAR is essential for proper temperature adaptation, a key behavior trait that is essentialFor survival of flies in the wild, and suggests a more general role of ADAR in regulating RNA secondary structures in vivo.