Elevated RNA Editing Activity Is a Major Contributor to Transcriptomic Diversity in Tumors.
Nurit Paz-Yaacov,Lily Bazak,Ilana Buchumenski,Hagit T. Porath,Miri Danan-Gotthold,Binyamin A. Knisbacher,Eli Eisenberg,Erez Y. Levanon +7 more
TLDR
It is shown that A-to-I editing and the enzymes mediating this modification are significantly altered, usually elevated, in most cancer types, and increased editing activity is found to be associated with patient survival.About:
This article is published in Cell Reports.The article was published on 2015-10-13 and is currently open access. It has received 253 citations till now. The article focuses on the topics: RNA editing & RNA.read more
Citations
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A-to-I editing of coding and non-coding RNAs by ADARs
TL;DR: Adenosine deaminases acting on RNA (ADARs) convert adenosine to inosine in double-stranded RNA, leading to reduced expression or altered function of mature miRNAs and certain microRNA precursors.
Journal ArticleDOI
Gene regulation in the immune system by long noncoding RNAs.
TL;DR: This Review focuses on mechanisms used by lncRNAs to regulate genes encoding products involved in the immune response, including direct interactions with chromatin, RNA and proteins, and addresses new areas of lncRNA biology.
Journal ArticleDOI
Loss of ADAR1 in tumours overcomes resistance to immune checkpoint blockade.
Jeffrey J. Ishizuka,Jeffrey J. Ishizuka,Robert T. Manguso,Robert T. Manguso,Collins K. Cheruiyot,Collins K. Cheruiyot,Kevin Bi,Kevin Bi,Arpit Panda,Arpit Panda,Arvin Iracheta-Vellve,Arvin Iracheta-Vellve,Brian C. Miller,Brian C. Miller,Peter P. Du,Peter P. Du,Kathleen B. Yates,Kathleen B. Yates,Juan Dubrot,Juan Dubrot,Ilana Buchumenski,Dawn E. Comstock,Dawn E. Comstock,Flavian D. Brown,Flavian D. Brown,Austin Ayer,Austin Ayer,Ian C. Kohnle,Ian C. Kohnle,Hans W. Pope,Hans W. Pope,Margaret D. Zimmer,Margaret D. Zimmer,Debattama R. Sen,Debattama R. Sen,Sarah Kate Lane-Reticker,Sarah Kate Lane-Reticker,Emily J. Robitschek,Emily J. Robitschek,Gabriel K. Griffin,Gabriel K. Griffin,Gabriel K. Griffin,Natalie B. Collins,Natalie B. Collins,Natalie B. Collins,Adrienne H. Long,Adrienne H. Long,John G. Doench,David Kozono,Erez Y. Levanon,W. Nicholas Haining,W. Nicholas Haining,W. Nicholas Haining +52 more
TL;DR: The induction of sufficient inflammation in tumours that are sensitized to interferon can bypass the therapeutic requirement for CD8+ T cell recognition of cancer cells and may provide a general strategy to overcome immunotherapy resistance.
Journal ArticleDOI
The Genomic Landscape and Clinical Relevance of A-to-I RNA Editing in Human Cancers.
Leng Han,Lixia Diao,Shuangxing Yu,Xiaoyan Xu,Xiaoyan Xu,Jie Li,Rui Zhang,Yang Yang,Yang Yang,Henrica M.J. Werner,Henrica M.J. Werner,A. Karina Eterovic,Yuan Yuan,Jun Li,Nikitha Nair,Rosalba Minelli,Yiu Huen Tsang,Lydia W.T. Cheung,Kang Jin Jeong,Jason Roszik,Zhenlin Ju,Scott E. Woodman,Yiling Lu,Kenneth L. Scott,Jin Billy Li,Gordon B. Mills,Han Liang +26 more
TL;DR: The effects of several cross-tumor nonsynonymous RNA editing events on cell viability are experimentally demonstrated and the evidence that RNA editing could selectively affect drug sensitivity is provided, highlighting RNA editing as an exciting theme for investigating cancer mechanisms, biomarkers, and treatments.
Journal ArticleDOI
A-to-I RNA editing — immune protector and transcriptome diversifier
Eli Eisenberg,Erez Y. Levanon +1 more
TL;DR: Next-generation sequencing technologies have enabled the comparison of editomes from multiple individuals and from multiple species and the results have changed the understanding of the extent and distribution of A-to-I editing and its role in evolution and disease.
References
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Teresiak,Honorata Tatka,Ewa Leporowska,Marta Bogusz-Czerniewicz,Julian Malicki,Andrzej Mackiewicz,Maciej Wiznerowicz,Xuan Van Le,Bernard Kohl,Nguyen Viet Tien,Richard Thorp,Nguyen Van Bang,Howard H. Sussman,Bui Duc Phu,Richard A. Hajek,Nguyen Phi Hung,Huynh Quyet Thang,Khurram Z. Khan,Robert Penny,David Mallery,Erin Curley,Candace Shelton,Peggy Yena,James N. Ingle,Fergus J. Couch,Wilma L. Lingle,Tari A. King,Ana M. Gonzalez-Angulo,Ana M. Gonzalez-Angulo,Mary D. Dyer,Shuying Liu,Xiaolong Meng,Modesto Patangan,Frederic Waldman,Frederic Waldman,Hubert Stoppler,W. Kimryn Rathmell,Leigh B. Thorne,Mei Huang,Lori Boice,Ashley Hill,Carl Morrison,Carmelo Gaudioso,Wiam Bshara,Kelly Daily,Sophie C. Egea,Mark D. Pegram,Carmen Gomez-Fernandez,Rajiv Dhir,Rohit Bhargava,Adam Brufsky,Craig D. Shriver,Jeffrey A. Hooke,Jamie Leigh Campbell,Richard J. Mural,Hai Hu,Stella Somiari,Caroline Larson,Brenda Deyarmin,Leonid Kvecher,Albert J. Kovatich,Matthew J. Ellis,Thomas Stricker,Kevin P. White,Olufunmilayo I. Olopade,Chunqing Luo,Yaqin Chen,Ron Bose,Li-Wei Chang,Andrew H. Beck,Todd Pihl,Mark A. Jensen,Robert Sfeir,Ari B. Kahn,Anna Chu,Prachi Kothiyal,Zhining Wang,Eric E. Snyder,Joan Pontius,Brenda Ayala,Mark Backus,Jessica Walton,Julien Baboud,Dominique L. Berton,Matthew C. Nicholls,Deepak Srinivasan,Rohini Raman,Stanley Girshik,Peter A. Kigonya,Shelley Alonso,Rashmi N. Sanbhadti,Sean P. Barletta,David Pot,Margi Sheth,John A. Demchok,Kenna R. Mills Shaw,Liming Yang,Greg Eley,Martin L. Ferguson,Roy Tarnuzzer,Jiashan Zhang,Laura A.L. Dillon,Kenneth H. Buetow,Peter Fielding,Bradley A. Ozenberger,Mark S. Guyer,Heidi J. Sofia,Jacqueline D. Palchik +355 more
TL;DR: The ability to integrate information across platforms provided key insights into previously defined gene expression subtypes and demonstrated the existence of four main breast cancer classes when combining data from five platforms, each of which shows significant molecular heterogeneity.
Journal ArticleDOI
Signatures of mutational processes in human cancer
Ludmil B. Alexandrov,Serena Nik-Zainal,Serena Nik-Zainal,David C. Wedge,Samuel Aparicio,Sam Behjati,Sam Behjati,Andrew V. Biankin,Graham R. Bignell,Niccolo Bolli,Niccolo Bolli,Åke Borg,Anne Lise Børresen-Dale,Anne Lise Børresen-Dale,Sandrine Boyault,Birgit Burkhardt,Adam Butler,Carlos Caldas,Helen Davies,Christine Desmedt,Roland Eils,Jorunn E. Eyfjord,John A. Foekens,Mel Greaves,Fumie Hosoda,Barbara Hutter,Tomislav Ilicic,Sandrine Imbeaud,Sandrine Imbeaud,Marcin Imielinsk,Natalie Jäger,David T. W. Jones,David T. Jones,Stian Knappskog,Stian Knappskog,Marcel Kool,Sunil R. Lakhani,Carlos López-Otín,Sancha Martin,Nikhil C. Munshi,Nikhil C. Munshi,Hiromi Nakamura,Paul A. Northcott,Marina Pajic,Elli Papaemmanuil,Angelo Paradiso,John V. Pearson,Xose S. Puente,Keiran Raine,Manasa Ramakrishna,Andrea L. Richardson,Andrea L. Richardson,Julia Richter,Philip Rosenstiel,Matthias Schlesner,Ton N. Schumacher,Paul N. Span,Jon W. Teague,Yasushi Totoki,Andrew Tutt,Rafael Valdés-Mas,Marit M. van Buuren,Laura van ’t Veer,Anne Vincent-Salomon,Nicola Waddell,Lucy R. Yates,Icgc PedBrain,Jessica Zucman-Rossi,Jessica Zucman-Rossi,P. Andrew Futreal,Ultan McDermott,Peter Lichter,Matthew Meyerson,Matthew Meyerson,Sean M. Grimmond,Reiner Siebert,Elias Campo,Tatsuhiro Shibata,Stefan M. Pfister,Stefan M. Pfister,Peter J. Campbell,Peter J. Campbell,Peter J. Campbell,Michael R. Stratton,Michael R. Stratton +84 more
TL;DR: It is shown that hypermutation localized to small genomic regions, ‘kataegis’, is found in many cancer types, and this results reveal the diversity of mutational processes underlying the development of cancer.