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Nurit Paz-Yaacov
Researcher at Sheba Medical Center
Publications - 7
Citations - 456
Nurit Paz-Yaacov is an academic researcher from Sheba Medical Center. The author has contributed to research in topics: RNA editing & Cancer. The author has an hindex of 4, co-authored 4 publications receiving 387 citations. Previous affiliations of Nurit Paz-Yaacov include Bar-Ilan University.
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Journal ArticleDOI
Elevated RNA Editing Activity Is a Major Contributor to Transcriptomic Diversity in Tumors.
Nurit Paz-Yaacov,Lily Bazak,Ilana Buchumenski,Hagit T. Porath,Miri Danan-Gotthold,Binyamin A. Knisbacher,Eli Eisenberg,Erez Y. Levanon +7 more
TL;DR: It is shown that A-to-I editing and the enzymes mediating this modification are significantly altered, usually elevated, in most cancer types, and increased editing activity is found to be associated with patient survival.
Journal ArticleDOI
Adenosine-to-inosine RNA editing shapes transcriptome diversity in primates
Nurit Paz-Yaacov,Erez Y. Levanon,Eviatar Nevo,Yaron Kinar,Alon Harmelin,Jasmine Jacob-Hirsch,Ninette Amariglio,Eli Eisenberg,Gideon Rechavi +8 more
TL;DR: It is shown here that combinatorial editing is the most significant contributor to the transcriptome repertoire and suggested that Alu editing adapted by natural selection may therefore serve as an alternate information mechanism based on the binary A/I code.
Journal ArticleDOI
Consistent levels of A-to-I RNA editing across individuals in coding sequences and non-conserved Alu repeats
Shoshana Greenberger,Shoshana Greenberger,Erez Y. Levanon,Nurit Paz-Yaacov,Aviv Barzilai,Michal Safran,Sivan Osenberg,Ninette Amariglio,Gideon Rechavi,Eli Eisenberg +9 more
TL;DR: The findings suggest that A-to-I RNA-editing of Alu elements is a tightly regulated process and, as such, might have been recruited in the course of primate evolution for post-transcriptional regulatory mechanisms.
Journal ArticleDOI
Induction of polyploidy by nuclear fusion mechanism upon decreased expression of the nuclear envelope protein LAP2β in the human osteosarcoma cell line U2OS
Shirley Oren Ben-Shoshan,Shirley Oren Ben-Shoshan,Amos J. Simon,Jasmine Jacob-Hirsch,Sigal Shaklai,Nurit Paz-Yaacov,Ninette Amariglio,Gideon Rechavi,Gideon Rechavi,Luba Trakhtenbrot +9 more
TL;DR: The results suggest that nuclear fusion mechanism underlies the polyploidization induction upon LAP2β reduced expression and implies on a novel role of LAP 2β in the maintenance of cell ploidy status.
Journal ArticleDOI
Direct identification of ALK and ROS1 fusions in non-small cell lung cancer from hematoxylin and eosin-stained slides using deep learning algorithms
Chen Mayer,Efrat Ofek,Danielle Even Fridrich,Yossef Molchanov,Rinat Yacobi,Inbal Gazy,I. Hayun,Jonathan Zalach,Nurit Paz-Yaacov,Iris Barshack +9 more
TL;DR: In this paper , an advanced convolutional neural network (CNN) was used to generate classifier models to detect ALK and ROS1-fusions directly from scanned hematoxylin and eosin (H&E) whole slide images prepared from NSCLC tumors of patients.