Ilkay Yildiz

TL;DR: Present results point out that, besides the very well-known bi- and ter-benzimidazoles, compounds with single bicycle fused ring systems in their structure such as benzimidrazole, benzoxazole, Benzothiazole, and/or oxazolopyridine derivatives also exhibit significant topoisomerase II inhibitory activity.

TL;DR: Some novel fused heterocyclic compounds of 2, 5-disubstituted-benzoxazole and benzimidazole derivatives, which were previously synthesized by the group, were investigated for their inhibitory activity on both eukaryotic DNA topoisomerase I and II in a cell free system.

TL;DR: A new series of 5(or 6)-nitro/amino-2-(substituted phenyl/benzyl)benzoxazole derivatives synthesized and evaluated for antibacterial and antifungal activities against Staphylococcus aureus, Bacillus subtilis, Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli, Candida albicans and their drug-resistant isolate.

TL;DR: The structure-activity relationship analysis of 2-(substitutedphenyl/benzyl)-5-[(2-benzofuryl)carboxamido]benzoxazoles using 3D-common features pharmacophore hypotheses approach is explored, considering the worth of developing new antibacterial agents against drug-resistant P. aeruginosa.

TL;DR: The template-based development of a small-molecule MV inhibitor is reported, providing proof-of-concept for the approach and may be applicable to other clinically relevant members of the paramyxovirus family.