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Ilona Rafalska
Researcher at University of Erlangen-Nuremberg
Publications - 5
Citations - 1826
Ilona Rafalska is an academic researcher from University of Erlangen-Nuremberg. The author has contributed to research in topics: Alternative splicing & RNA splicing. The author has an hindex of 5, co-authored 5 publications receiving 1607 citations.
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Journal ArticleDOI
Function of alternative splicing.
Stefan Stamm,Shani Ben-Ari,Ilona Rafalska,Yesheng Tang,Zhaiyi Zhang,Debra Toiber,Thangavel Alphonse Thanaraj,Hermona Soreq +7 more
TL;DR: Evidence is now accumulating that alternative splicing coordinates physiologically meaningful changes in protein isoform expression and is a key mechanism to generate the complex proteome of multicellular organisms.
Journal ArticleDOI
The YTH domain is a novel RNA binding domain.
Zhaiyi Zhang,Dominik Theler,Katarzyna Kamińska,Katarzyna Kamińska,Michael Hiller,Pierre de la Grange,Rainer Pudimat,Ilona Rafalska,Bettina Heinrich,Janusz M. Bujnicki,Janusz M. Bujnicki,Frédéric H.-T. Allain,Stefan Stamm +12 more
TL;DR: The YTH domain is a novel RNA binding domain that binds to a short, degenerated, single-stranded RNA sequence motif that conveys RNA binding ability to a new class of proteins found in all eukaryotic organisms.
Journal ArticleDOI
YTH: a new domain in nuclear proteins.
TL;DR: A novel 100-150-residue domain has been identified in the human splicing factor YT521-B and its Drosophila and yeast homologues and it is predicted to adopt a mixed alpha-helix-beta-sheet fold and to bind to RNA.
Journal ArticleDOI
The intranuclear localization and function of YT521-B is regulated by tyrosine phosphorylation
Ilona Rafalska,Zhaiyi Zhang,Natalya Benderska,Horst Wolff,Annette M. Hartmann,Ruth Brack-Werner,Stefan Stamm +6 more
TL;DR: It is proposed that tyrosine phosphorylation causes sequestration of YT521-B in an insoluble nuclear form, which abolishes the ability ofYT5 21-B to change alternative splice sites.
Book ChapterDOI
Pre-mRNA Missplicing as a Cause of Human Disease
TL;DR: These findings prove the principle that diseases caused by missplicing events could eventually be cured and a growing number of low molecular weight drugs have been discovered that influence splice site selection in vivo.