Z
Zhaiyi Zhang
Researcher at University of Kentucky
Publications - 9
Citations - 2142
Zhaiyi Zhang is an academic researcher from University of Kentucky. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 4, co-authored 5 publications receiving 1911 citations. Previous affiliations of Zhaiyi Zhang include University of Erlangen-Nuremberg.
Papers
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Journal ArticleDOI
Function of alternative splicing.
Stefan Stamm,Shani Ben-Ari,Ilona Rafalska,Yesheng Tang,Zhaiyi Zhang,Debra Toiber,Thangavel Alphonse Thanaraj,Hermona Soreq +7 more
TL;DR: Evidence is now accumulating that alternative splicing coordinates physiologically meaningful changes in protein isoform expression and is a key mechanism to generate the complex proteome of multicellular organisms.
Journal ArticleDOI
ReviewFunction of alternative splicing
Olga Kelemen,Paolo Convertini,Zhaiyi Zhang,Yuan Wen,Manli Shen,Marina Falaleeva,Stefan Stamm +6 more
TL;DR: The overall function of alternative splicing is to increase the diversity of mRNAs expressed from the genome as mentioned in this paper, which can have profound functional effects, such as increasing cell proliferation, cell survival and properties of the nervous system.
Journal ArticleDOI
Pre-mRNA Secondary Structures Influence Exon Recognition
TL;DR: The secondary structure context of experimentally determined splicing enhancer and silencer motifs in their natural pre-mRNA context is analyzed and it is found that these splicing motifs are significantly more single-stranded than controls.
Journal ArticleDOI
The intranuclear localization and function of YT521-B is regulated by tyrosine phosphorylation
Ilona Rafalska,Zhaiyi Zhang,Natalya Benderska,Horst Wolff,Annette M. Hartmann,Ruth Brack-Werner,Stefan Stamm +6 more
TL;DR: It is proposed that tyrosine phosphorylation causes sequestration of YT521-B in an insoluble nuclear form, which abolishes the ability ofYT5 21-B to change alternative splice sites.
Journal ArticleDOI
Response to Brosch et al
Jussi Pihlajamäki,Carles Lerin,Dorota Kaminska,Sari Venesmaa,Paula Itkonen,Tanner Boes,Thomas Floss,Joshua Schroeder,Farrell Dearie,Sarah Crunkhorn,Furkan Burak,Josep C. Jimenez-Chillaron,Tiina Kuulasmaa,Pekka Miettinen,Peter J. Park,Imad Nasser,Zhenwen Zhao,Zhaiyi Zhang,Yan Xu,Wolfgang Wurst,Hongmei Ren,Andrew J. Morris,Stefan Stamm,Allison B. Goldfine,Markku Laakso,Mary-Elizabeth Patti +25 more
TL;DR: The paper addresses points raised by Brosch, including experimental strategy and analysis of human SFRS10 expression, and performs RT-PCR in liver samples from 13 lean and 34 obese individuals, finding no differences inSFRS10 or LPIN1 expression.