E
E De Plaen
Researcher at Ludwig Institute for Cancer Research
Publications - 31
Citations - 10043
E De Plaen is an academic researcher from Ludwig Institute for Cancer Research. The author has contributed to research in topics: Antigen & Gene. The author has an hindex of 21, co-authored 28 publications receiving 9790 citations. Previous affiliations of E De Plaen include University of Mainz & Université catholique de Louvain.
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Journal ArticleDOI
A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma
P. van der Bruggen,Catia Traversari,Patrick Chomez,Christophe Lurquin,E De Plaen,B Van den Eynde,Alexander Knuth,Thierry Boon +7 more
TL;DR: In this paper, a gene was identified that directed the expression of antigen MZ2-E on a human melanoma cell line, which belongs to a family of at least three genes.
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A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma
Thomas Wölfel,M. Hauer,Jörg Schneider,Manuel Serrano,Catherine Wölfel,E Klehmann-Hieb,E De Plaen,Thomas Hankeln,K H Meyer zum Büschenfelde,D Beach +9 more
TL;DR: Results suggest that mutation of CDK4 can create a tumor-specific antigen and can disrupt the cell-cycle regulation exerted by the tumor suppressor p16INK4a.
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The tyrosinase gene codes for an antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas.
Vincent Brichard,A Van Pel,T. Wölfel,C Wölfel,E De Plaen,Bernard Lethe,Pierre Coulie,Thierry Boon +7 more
TL;DR: The cloning of a cDNA is reported that directs the expression of the antigen recognized by HLA-A2 melanoma patients, and this cDNA corresponds to the transcript of the tyrosinase gene.
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A new gene coding for a differentiation antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas
Pierre Coulie,Vincent Brichard,A Van Pel,T. Wölfel,Jörg Schneider,Catia Traversari,S Mattei,E De Plaen,Christophe Lurquin,Jean-Pierre Szikora,Jean-Christophe Renauld,Thierry Boon +11 more
TL;DR: The Melan-A gene as discussed by the authors was identified as a gene that also directs the expression of an antigen recognized on most melanomas by CTL clones that are restricted by HLA-A2.
Journal ArticleDOI
Human gene MAGE-3 codes for an antigen recognized on a melanoma by autologous cytolytic T lymphocytes.
Beatrice Gaugler,B Van den Eynde,P. van der Bruggen,Pedro Romero,José J. Gaforio,E De Plaen,Bernard Lethe,Francis Brasseur,Thierry Boon +8 more
TL;DR: It is shown here that antigen MZ2-D, which is present on the same tumor, is encoded by another member of the MAGE gene family named MAGE-3, which may have a wide applicability for specific immunotherapy of melanoma patients.