Philippe Guillaume

TL;DR: These findings support the use of Tim-3–Tim-3L blockade together with PD-1–PD-L1 blockade to reverse tumor-induced T cell exhaustion/dysfunction in patients with advanced melanoma.

TL;DR: It is shown that the inhibitory Ly49A NK cell receptor not only binds to its H-2Dd ligand expressed on potential target cells but also is constitutively associated with H- 2Dd in cis (on the same cell).

TL;DR: Unbiased mass spectrometry with a motif deconvolution algorithm is combined to profile and analyze a total of 99,265 unique peptides eluted from HLA-II molecules and train an epitope prediction algorithm that improves prediction of pathogen and tumor-associated class II neoepitopes.

TL;DR: This work reports an unexpected high frequency of T cells specific for the self-antigen Melan-A/MART-1 in CD8 single–positive thymocytes from human histocompatibility leukocyte antigen-A2 healthy individuals, which is maintained in the peripheral blood of newborns and adults.

TL;DR: The characterization of the structure‐function properties of the melanocyte/melanoma tumor antigen Melan‐A/MART‐1 is described, the assessment of the T‐cell repertoire available against this antigen in healthy individuals, and the analysis of naturally acquired and/or vaccine‐induced CTL responses toThis antigen in patients with metastatic melanoma are described.