Imre Szabó

TL;DR: Evidence is provided that prostaglandin E2 (PGE2) rapidly phosphorylates EGFR and triggers the extracellular signal-regulated kinase 2 (ERK2)–mitogenic signaling pathway in normal gastric epithelial and colon cancer cell lines, revealing a previously unknown mechanism by which PGE2 mediates trophic actions resulting in gastric and intestinal hypertrophy as well as growth of colonic polyps and cancers.

TL;DR: The data suggest that PGE(2)-stimulates VEGF expression in RGMEC via transactivation of JNK1 by ERK2, and increased PG levels in cancers could facilitate tumor growth by stimulating V EGF synthesis and angiogenesis.

TL;DR: Analysis of a large, nationwide, prospective cohort of AP cases allowed for the identification of important determinants of severity and mortality, and evidence-based guidelines should be observed rigorously to improve outcomes in AP.

TL;DR: This meta-analysis provides high-grade evidence of an improved general symptom score among patients with irritable bowel syndrome who have maintained a low-FODMAP diet compared to those on a traditional IBS diet, therefore showing its superiority to regular IBS dietary therapy.

TL;DR: During ulcer healing expression of growth factor genes is tightly regulated in a temporally and spatially ordered manner, allowing for the reconstruction of microvasculature in the mucosal scar, which is essential for delivery of oxygen and nutrients to the healing site.