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In-Woo Park
Researcher at Harvard University
Publications - 11
Citations - 957
In-Woo Park is an academic researcher from Harvard University. The author has contributed to research in topics: Simian immunodeficiency virus & Virus. The author has an hindex of 8, co-authored 9 publications receiving 940 citations.
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A chimeric simian/human immunodeficiency virus expressing a primary patient human immunodeficiency virus type 1 isolate env causes an AIDS-like disease after in vivo passage in rhesus monkeys.
Keith A. Reimann,J T Li,Ronald S. Veazey,Matilda Halloran,In-Woo Park,Gunilla B. Karlsson,Joseph Sodroski,Norman L. Letvin +7 more
TL;DR: It is shown that after two serial in vivo passages by intravenous blood inoculation of naive rhesus monkeys, this SHIV (SHIV-89.6P) induced CD4 lymphopenia and an AIDS-like disease with wasting and opportunistic infections.
Journal ArticleDOI
Characterization of molecularly cloned simian-human immunodeficiency viruses causing rapid CD4+ lymphocyte depletion in rhesus monkeys.
Gunilla B. Karlsson,Matilda Halloran,John Li,In-Woo Park,Raul Gomila,Keith A. Reimann,Michael K. Axthelm,Susan A. Iliff,Norman L. Letvin,Joseph Sodroski +9 more
TL;DR: The availability of pathogenic proviral clones should facilitate dissection of the molecular determinants of SHIV-89.6P virulence, and the molecular changes responsible for this increase in virulence were characterized.
Journal ArticleDOI
Molecular determinants of acute single-cell lysis by human immunodeficiency virus type 1.
TL;DR: It is suggested that intracellular envelope glycoprotein-CD4 interactions initiate autofusion events that disrupt cell membrane integrity, leading to single-cell lysis by HIV-1.
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Functional analysis of the vpx, vpr, and nef genes of simian immunodeficiency virus.
In-Woo Park,Joseph Sodroski +1 more
TL;DR: The role of the vpx, vpr, and nef genes in the replication of simian immunodeficiency virus (SIV) was investigated using point and deletion mutations in these genes.
Journal ArticleDOI
Characterization of multiple mRNA species of simian immunodeficiency virus from macaques in a CD4+ lymphoid cell line.
TL;DR: The authors' results demonstrate a complex pattern of alternative splicing of SIV mRNAs, very similar to what has been observed in human immunodeficiency virus type 1-infected cells, suggesting that both human and simian immunideficiency viruses are subject to multiple levels of regulation.