Inchan Kwon

TL;DR: Molecular engineering and directed evolution of AAV vectors offer promise for generating ‘designer’ gene delivery vectors with enhanced properties, particularly those based on AAV2, the best characterized AAV serotype.

TL;DR: An E. coli strain co-transformed with ytRNAPheAAA and a mutant yeast phenylalanyl-tRNA synthetase is used to demonstrate efficient replacement of phenylalanine by L-3-(2-naphthyl)alanine (Nal) at UUU, but not at UUC codons.

TL;DR: An overview of the recent progress in the development of novel nanomaterials for the alleviation of hypoxic microenvironment is presented, with promising start in the early phase and expected to grow rapidly in the coming years.

TL;DR: This work applied directed evolution to create a "designer" AAV vector with enhanced delivery efficiency for neural stem cells (NSCs), and a novel AAV variant, carrying an insertion of a selected peptide sequence on the surface of the threefold spike within the heparin-binding site, emerged from this evolution.

TL;DR: It is demonstrated that BBG is an effective Aβ aggregation modulator, which reduces Aβ-associated cytotoxicity in a dose-dependent manner by promoting the formation of off-pathway, nontoxic aggregates and supports the hypothesis that generating nont toxic aggregates using small molecule modulators is aneffective strategy for reducing Aβ cytot toxicity.