Journal ArticleDOI
Improving cancer therapy through the nanomaterials-assisted alleviation of hypoxia.
TLDR
An overview of the recent progress in the development of novel nanomaterials for the alleviation of hypoxic microenvironment is presented, with promising start in the early phase and expected to grow rapidly in the coming years.About:
This article is published in Biomaterials.The article was published on 2020-01-01. It has received 129 citations till now. The article focuses on the topics: Tumor hypoxia.read more
Citations
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Journal ArticleDOI
Conquering the Hypoxia Limitation for Photodynamic Therapy
TL;DR: In this article, a review of the recent progress in new nanomaterials designed to combat hypoxia and avoid the associated limitation of photodynamic therapy (PDT) is presented.
Journal ArticleDOI
Activatable nanomedicine for overcoming hypoxia-induced resistance to chemotherapy and inhibiting tumor growth by inducing collaborative apoptosis and ferroptosis in solid tumors.
TL;DR: An ultrasound (US)-activatable nanomedicine was developed for overcoming hypoxia-induced resistance to chemotherapy and efficiently inhibiting tumor growth by inducing sensitized apoptosis and collaborative ferroptosis of tumor cells, showing great potential as theranostic agents for hypoxic solid tumors treatment.
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Recent advances in MOF-based nanoplatforms generating reactive species for chemodynamic therapy
Yuyu Zhong,Xiaosan Li,Junhao Chen,Xiaoxiong Wang,Lin-Tao Wei,Liqing Fang,Abhinav Kumar,Shuze Zhuang,Jianqiang Liu +8 more
TL;DR: This review focuses on summarizing the use of MOFs in CDT and their synergetic therapeutics as well as the challenges, obstacles, and development.
Journal ArticleDOI
Injectable redox and light responsive MnO2 hybrid hydrogel for simultaneous melanoma therapy and multidrug-resistant bacteria-infected wound healing.
TL;DR: An injectable redox and light responsive bio-inspired MnO2 hybrid (BMH) hydrogel for effective melanoma photothermo-chemotherapy and MDR bacteria infected-wound healing and could alleviate the hypoxic tumor microenvironment (TME) by decomposing the endogenous H2O2 into O2, and simultaneously release anticancer drug DOX.
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Cell primitive-based biomimetic functional materials for enhanced cancer therapy.
TL;DR: The most recent advances in the development of cell primitive-based functional materials for cancer therapy are summarized and strategies in combining with synthetic materials, especially nanoparticulate systems, for the construction of function-enhanced biomaterials are summarized.
References
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Journal ArticleDOI
The Chemistry and Applications of Metal-Organic Frameworks
Hiroyasu Furukawa,Hiroyasu Furukawa,Kyle E. Cordova,Kyle E. Cordova,Michael O'Keeffe,Michael O'Keeffe,Omar M. Yaghi,Omar M. Yaghi,Omar M. Yaghi +8 more
TL;DR: Metal-organic frameworks are porous materials that have potential for applications such as gas storage and separation, as well as catalysis, and methods are being developed for making nanocrystals and supercrystals of MOFs for their incorporation into devices.
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Introduction to Metal–Organic Frameworks
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Multidrug resistance in cancer: role of ATP–dependent transporters
TL;DR: The ability to predict and circumvent drug resistance is likely to improve chemotherapy, and it has become apparent that resistance exists against every effective drug, even the authors' newest agents.
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Normalization of Tumor Vasculature: An Emerging Concept in Antiangiogenic Therapy
TL;DR: Emerging evidence supporting an alternative hypothesis is reviewed—that certain antiangiogenic agents can also transiently “normalize” the abnormal structure and function of tumor vasculature to make it more efficient for oxygen and drug delivery.
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Hypoxia — a key regulatory factor in tumour growth
TL;DR: Cells undergo a variety of biological responses when placed in hypoxic conditions, including activation of signalling pathways that regulate proliferation, angiogenesis and death, and many elements of the hypoxia-response pathway are good candidates for therapeutic targeting.