Inder M. Verma

TL;DR: It is shown that normal cellular protein can induce transformation when expressed in an inappropriate cell type, and even though the c-fos protein is completely different from the v- fos protein at its C terminus, it is capable of transforming cultured fibroblasts.

TL;DR: It is proposed that most differentiated cells in the CNS upon defined genetic alterations undergo dedifferentiation to generate a NSC or progenitor state to initiate and maintain the tumor progression, as well as to give rise to the heterogeneous populations observed in malignant gliomas.

TL;DR: Using a combination of behavioural analysis of six inbred mouse strains with quantitative gene expression profiling of several brain regions, the identification of 17 genes with expression patterns that correlate with anxiety-like behavioural phenotypes are identified.

TL;DR: In this article, a combination of behavioural analysis of six inbred mouse strains with quantitative gene expression profiling of several brain regions was used to identify 17 genes with expression patterns that correlate with anxiety-like behavioural phenotypes.

TL;DR: The similarities between tumor dedifferentiation and somatic cell reprogramming are discussed and how this may pose a risk to the application of this new technology in regenerative medicine.