D
Dinorah Friedmann-Morvinski
Researcher at Tel Aviv University
Publications - 45
Citations - 3694
Dinorah Friedmann-Morvinski is an academic researcher from Tel Aviv University. The author has contributed to research in topics: Cancer & Glioma. The author has an hindex of 22, co-authored 37 publications receiving 2931 citations. Previous affiliations of Dinorah Friedmann-Morvinski include Weizmann Institute of Science & Salk Institute for Biological Studies.
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Journal ArticleDOI
Dedifferentiation of neurons and astrocytes by oncogenes can induce gliomas in mice.
Dinorah Friedmann-Morvinski,Eric A. Bushong,Eugene Ke,Eugene Ke,Yasushi Soda,Tomotoshi Marumoto,Tomotoshi Marumoto,Oded Singer,Mark H. Ellisman,Inder M. Verma +9 more
TL;DR: It is proposed that most differentiated cells in the CNS upon defined genetic alterations undergo dedifferentiation to generate a NSC or progenitor state to initiate and maintain the tumor progression, as well as to give rise to the heterogeneous populations observed in malignant gliomas.
Journal ArticleDOI
Transdifferentiation of glioblastoma cells into vascular endothelial cells
Yasushi Soda,Tomotoshi Marumoto,Tomotoshi Marumoto,Dinorah Friedmann-Morvinski,Mie Soda,Fei Liu,Hiroyuki Michiue,Sandra Pastorino,Meng Yang,Robert M. Hoffman,Santosh Kesari,Inder M. Verma +11 more
TL;DR: It is suggested that the TDEC is an important player in the resistance to anti-VEGF therapy, and hence a potential target for GBM therapy.
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Dedifferentiation and reprogramming: origins of cancer stem cells
TL;DR: The similarities between tumor dedifferentiation and somatic cell reprogramming are discussed and how this may pose a risk to the application of this new technology in regenerative medicine.
Journal ArticleDOI
Targeted nanoparticle enhanced proapoptotic peptide as potential therapy for glioblastoma
Lilach Agemy,Dinorah Friedmann-Morvinski,Venkata Ramana Kotamraju,Lise Roth,Kazuki N. Sugahara,Olivier M. Girard,Robert F. Mattrey,Inder M. Verma,Erkki Ruoslahti,Erkki Ruoslahti +9 more
TL;DR: Systemic treatment of GBM-bearing mice with the nanoparticles eradicated most tumors in one GBM mouse model and significantly delayed tumor development in another, suggesting clinical potential of the nanosystem.
Journal ArticleDOI
Development of a novel mouse glioma model using lentiviral vectors
Tomotoshi Marumoto,Ayumu Tashiro,Dinorah Friedmann-Morvinski,Miriam Scadeng,Yasushi Soda,Fred H. Gage,Inder M. Verma +6 more
TL;DR: It is suggested that the use of Cre-loxP–controlled lentiviral vectors is a novel way to generate a mouse glioblastoma multiforme model in a region- and cell type-specific manner in adult mice.