I
Indika Rajapakse
Researcher at University of Michigan
Publications - 85
Citations - 3846
Indika Rajapakse is an academic researcher from University of Michigan. The author has contributed to research in topics: Genome & Chromosome conformation capture. The author has an hindex of 18, co-authored 76 publications receiving 2908 citations. Previous affiliations of Indika Rajapakse include Washington State University & Johns Hopkins University.
Papers
More filters
Journal ArticleDOI
Genome-wide Methylation Profiles Reveal Quantitative Views of Human Aging Rates
Gregory Hannum,Justin Guinney,Ling Zhao,Ling Zhao,Li Zhang,Guy Hughes,Srinivas R. Sadda,Brandy Klotzle,Marina Bibikova,Jian-Bing Fan,Yuan Gao,Rob Deconde,Menzies Chen,Indika Rajapakse,Stephen H. Friend,Trey Ideker,Kang Zhang,Kang Zhang +17 more
TL;DR: A quantitative model of aging is built using measurements at more than 450,000 CpG markers from the whole blood of 656 human individuals, aged 19 to 101, to measure the rate at which an individual's methylome ages, which is impacted by gender and genetic variants.
Journal ArticleDOI
On emerging nuclear order.
Indika Rajapakse,Mark Groudine +1 more
TL;DR: Technological advances now provide genome-wide and four-dimensional analyses, permitting global characterizations of nuclear order, and will help uncover how seemingly separate nuclear processes may be coupled and aid in the effort to understand the role of nuclear organization in development and disease.
Journal ArticleDOI
Transcripts involved in calcium signaling and telencephalic neuronal fate are altered in induced pluripotent stem cells from bipolar disorder patients.
Haiming Chen,Cynthia J. DeLong,Monica Bame,Indika Rajapakse,Todd J. Herron,Melvin G. McInnis,K S O’Shea +6 more
TL;DR: Examination of changes in gene expression as iPSC derived from well-characterized patients differentiate into neurons found BP neurons were significantly different than controls in their transcriptional profile, and lithium pretreatment of BP neurons significantly altered their calcium transient and wave amplitude.
Journal ArticleDOI
Functional organization of the human 4D Nucleome
Haiming Chen,Jie Chen,Lindsey A. Muir,Scott Ronquist,Walter Meixner,Mats Ljungman,Thomas Ried,Steve Smale,Indika Rajapakse +8 more
TL;DR: The results show that structural features of genomic regions correlate with function with surprising persistence over time, and a quantitative index that measures underlying topological stability of a genomic region is introduced.
Journal ArticleDOI
The emergence of lineage-specific chromosomal topologies from coordinate gene regulation
Indika Rajapakse,Michael D. Perlman,David Scalzo,Charles Kooperberg,Mark Groudine,Mark Groudine,Steven T. Kosak +6 more
TL;DR: This work model the dynamic relationship between gene expression and chromosomal associations during the differentiation of a multipotential hematopoietic progenitor and reveals dramatic changes in total genomic order.