Ingrid A. Boere

TL;DR: Prenatal exposure to maternal cancer with or without treatment did not impair the cognitive, cardiac, or general development of children in early childhood andPrematurity was correlated with a worse cognitive outcome, but this effect was independent of cancer treatment.

TL;DR: It is found that carboplatin and paclitaxel disposition are stable phenotypes in ovarian cancer patients and genome-wide association study (GWAS) of chemotherapeutic drug disposition can be effective, even in relatively small cohorts, and can be adopted in drug development and treatment programs.

TL;DR: In situ light dosimetry was used to adjust the fluence rate measured within the esophagus for individual animals and monitored protoporphyrin IX (PpIX) fluorescence photobleaching simultaneously, and it was found that higher PpIX fluorescence photography rates corresponded with more epithelial damage, whereas lower rates corresponding with no response.

TL;DR: A multivariate classification model was developed for detection of Barrett's epithelium, based on ex vivo Raman spectra of the rat oesophagus, and this model yields a spectral discriminant that best separates the two groups.

TL;DR: In vivo dosimetry is feasible in heterogeneous conditions such as BE, and PpIX fluorescence photobleaching is useful to predict the tissue response to ALA-PDT, as observed in a rat model of BE.