Inthrani Raja Indran

TL;DR: An overview of the recent understanding of apoptotic signaling pathways, the main mechanisms by which cancer cells resist apoptotic insults, and some recent attempts to target the mitochondrion for restoring efficient cell death signaling in cancer cells are provided.

TL;DR: It is shown that hTERT overexpression not only reduces the basal cellular reactive oxygen species (ROS) levels but also inhibits endogenous ROS production in response to stimuli that induce intracellular ROS generation, and in doing so endowing cancer cells with the ability to evade death stimuli.

TL;DR: Clinical trials have reported positive effects on bone health, suggesting that compounds or extracts of Epimedium have the potential to be developed as agents, alone or in combination with other drugs, to prevent or delay the onset of osteoporosis and reduce the risk of hip fractures.

TL;DR: Novel findings are presented that ICT, by downregulating TRAF6, coordinates inhibition of NF‐κB, MAPK/AP‐1, and ROS signaling pathways to reduce expression and activity of NFATc1.

TL;DR: It is reported for the first time that a natural prenylflavonoid, icaritin (ICT), can co-target both persistent AR and ARvs, and provide a mechanistic framework for the development of ICT, as a novel lead compound for AR-positive PC therapeutics, especially for those bearing AR splice variants.