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Irina Alho
Researcher at Instituto de Medicina Molecular
Publications - 41
Citations - 847
Irina Alho is an academic researcher from Instituto de Medicina Molecular. The author has contributed to research in topics: Bone metastasis & Cancer. The author has an hindex of 16, co-authored 41 publications receiving 674 citations. Previous affiliations of Irina Alho include University of Lisbon.
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Bone metastasis risk factors in breast cancer.
Catarina Pulido,Ines Vendrell,Arlindo R. Ferreira,Sandra Casimiro,André Mansinho,Irina Alho,Luis Costa +6 more
TL;DR: Knowledge of risk factors related with bone disease is of paramount importance as it might be a prediction tool for triggering the use of targeted agents and allow for better patient selection for future clinical trials.
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RANKL/RANK/MMP-1 molecular triad contributes to the metastatic phenotype of breast and prostate cancer cells in vitro.
Sandra Casimiro,Khalid S. Mohammad,Ricardo A. Pires,Joana Tato-Costa,Irina Alho,Rui Pedro A. G. Teixeira,Antonio J. F. Carvalho,Sofia Ribeiro,Allan Lipton,Theresa A. Guise,Luis Costa +10 more
TL;DR: In vivo, MMP-1 knockdown resulted in smaller x-ray osteolytic lesions and osteoclastogenesis, and decreased tumor burden, suggesting RANKL inhibition in bone metastatic disease may decrease the levels of the osteOClastogenesis inducer M MP-1, contributing to a better clinical outcome.
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Therapy-Induced Cellular Senescence Induces Epithelial-to-Mesenchymal Transition and Increases Invasiveness in Rectal Cancer
Joana Tato-Costa,Sandra Casimiro,Teresa R. Pacheco,Ricardo A. Pires,Afonso Fernandes,Irina Alho,Pedro Pereira,Paulo Costa,Henrique Bicha Castelo,João Sette Whitaker Ferreira,Luis Costa +10 more
TL;DR: First-hand, strongly suggestive evidence is provided that senescent cancer cells emerging in the context of neoadjuvant CRT for rectal cancer influenced the tumor microenvironment by promoting EMT by way of short-range interactions.
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GST M1/T1 and MTHFR polymorphisms as risk factors for hypertension.
Cláudia Marinho,Irina Alho,Daniela Arduíno,Luiz Menezes Falcão,José Brás-Nogueira,Manuel Bicho +5 more
TL;DR: GSH depletion confirmed the possible involvement of oxidative stress in this pathology and deletion of GSTT1 gene might be considered as protective factor for hypertension.
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New Cu(II) complexes with pyrazolyl derived Schiff base ligands: Synthesis and biological evaluation.
Nádia Ribeiro,Somnath C. Roy,Nataliya Butenko,Nataliya Butenko,Isabel Cavaco,Isabel Cavaco,Teresa Pinheiro,Irina Alho,Fernanda Marques,Fernando Avecilla,João Costa Pessoa,Isabel Correia +11 more
TL;DR: The results suggest that the mechanisms of cell death do not seem to be mediated by apoptosis, through caspases 3/7 activation, but by involving membrane potential and imbalance in physiological elements such as P, K and Ca.