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Irina Pleines
Researcher at University of Würzburg
Publications - 42
Citations - 3066
Irina Pleines is an academic researcher from University of Würzburg. The author has contributed to research in topics: Platelet & Platelet activation. The author has an hindex of 20, co-authored 41 publications receiving 2661 citations. Previous affiliations of Irina Pleines include University of Melbourne & Walter and Eliza Hall Institute of Medical Research.
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Journal ArticleDOI
Cell Adhesion Mechanisms in Platelets
TL;DR: This review summarizes the most important structural and functional properties of these adhesion receptors and briefly discusses their potential as targets for antithrombotic therapy.
Journal ArticleDOI
Interleukin-11 Is the Dominant IL-6 Family Cytokine during Gastrointestinal Tumorigenesis and Can Be Targeted Therapeutically
Tracy L Putoczki,Tracy L Putoczki,Stefan Thiem,Andrea Loving,Rita A. Busuttil,Rita A. Busuttil,Nicholas J. Wilson,Paul Ziegler,Paul M Nguyen,Adele Preaudet,Ryan Farid,Kirsten Edwards,Yeliz Boglev,Rodney B. Luwor,Andrew G. Jarnicki,David Horst,Alex Boussioutas,Alex Boussioutas,Joan K. Heath,Oliver M. Sieber,Irina Pleines,Benjamin T. Kile,Andrew D. Nash,Florian R. Greten,Brent S. McKenzie,Matthias Ernst,Matthias Ernst +26 more
TL;DR: Using genetic mouse models and in human tumor cell line xenograft models, pharmacologic inhibition of IL-11 signaling alleviated STAT3 activation, suppressed tumor cell proliferation, and reduced the invasive capacity and growth of tumors.
Journal ArticleDOI
Platelet adhesion and activation mechanisms in arterial thrombosis and ischaemic stroke.
TL;DR: Recent experimental evidence now suggests that early platelet adhesion and activation events, orchestrate a ‘thrombo‐inflammatory’ cascade in this setting, whereas platelet aggregation and thrombus formation are not required.
Journal ArticleDOI
Loss of talin1 in platelets abrogates integrin activation, platelet aggregation, and thrombus formation in vitro and in vivo
Bernhard Nieswandt,Markus Moser,Irina Pleines,David Varga-Szabo,Susan J. Monkley,David R. Critchley,Reinhard Fässler +6 more
TL;DR: It is demonstrated that platelets from mice lacking talin1 are unable to activate integrins in response to all known major platelet agonists while other cellular functions are still preserved and mice with talin-deficient platelets display a severe hemostatic defect and are completely resistant to arterial thrombosis.
Journal ArticleDOI
The calcium sensor STIM1 is an essential mediator of arterial thrombosis and ischemic brain infarction
David Varga-Szabo,Attila Braun,Christoph Kleinschnitz,Markus Bender,Irina Pleines,Mirko Pham,Thomas Renné,Guido Stoll,Bernhard Nieswandt +8 more
TL;DR: STIM1 is established as an important mediator in the pathogenesis of ischemic cardio- and cerebrovascular events in mice with STIM1-deficient platelets, which are significantly protected from arterial thrombosis and isChemic brain infarction but have only a mild bleeding time prolongation.