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Irma Mebane-Sims
Publications - 7
Citations - 2905
Irma Mebane-Sims is an academic researcher. The author has contributed to research in topics: Estrogen & Medroxyprogesterone acetate. The author has an hindex of 7, co-authored 7 publications receiving 2862 citations.
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Journal ArticleDOI
Effects of Estrogen or Estrogen/ Progestin Regimens on Heart Disease Risk Factors in Postmenopausal Women: The Postmenopausal Estrogen/Progestin Interventions (PEPI) Trial
Valery T. Miller,John C. LaRosa,Vanessa M. Barnabei,Craig M. Kessler,Ginny Levin,Ann Smith-Roth,Margaret Griffin,Diane B. Stoy,Trudy L. Bush,Howard A. Zacur,David A. Foster,Jean Anderson,Alice McKenzie,Susan C. Miller,Peter D. Wood,Marcia L. Stefanick,Robert Marcus,Allison Akana,W. Leroy Heinrichs,Charlene Kirchner,Katherine A. O'Hanlan,Melissa Ruyle,Mary A. Sheehan,Howard L. Judd,Gail A. Greendale,Richard Bayalos,Kathy Lozano,Kathy Kawakami,Elizabeth Barrett-Connor,Robert Langer,Donna Kritz-Silverstein,Mary Lou Carrion-Petersen,Carmela Cavero,Helmut G. Schrott,Susan R. Johnson,Deborah A. Feddersen,Denise L. Krutzfeldt,Jo Ann Benda,Carl J. Pauerstein,Jose Trabal,Robert S. Schenken,Michael P. Stern,Mercedes Rodriguez-Sifuentes,Carann Easton,H B Wells,Mark A. Espeland,George Howard,Robert Byington,Claudine Legault,Sally A. Shumaker,Patricia E. Hogan,Don Hire,Carol Wasilauskas,Margaret K. James,Kathy Lane,Tim Terrell,Stephanie Reece,June J Pierce,Mary Snow,Susan Anthony,Irma Mebane-Sims,Paula T. Einhorn,Sally Hunsberger,Myron A. Waclawiw,Ken Lippel,Diane L. Lucas,Joel Verter,Sherry Jackson,Joseph Kelaghan,Jeffrey M. Perlman,Pam Wolf,Joan McGowan,Stephen Gordon,Stephen Heyse,Judith E. Fradkin,Sherry Sherman,Lot B. Page,Ann Sorenson,Barbara S. Hulka,Baruch A. Brody,Ronald T. Burkman,Robert P. Heaney,Ronald M. Krauss,Harold Roberts,Janet Wittes,Lawrence Riggs,Richard Moss,John J. Albers,Santica M. Marcovina,S. Edwin Fineberg,Russell P. Tracy,Maria J. Merino,Robert E. Scully,Virginia A. LiVolsi,Gerald Kessler +94 more
TL;DR: Estrogen alone or in combination with a progestin improves lipoproteins and lowers fibrinogen levels without detectable effects on postchallenge insulin or blood pressure and in women with a uterus, CEE with cyclic MP has the most favorable effect on HDL-C and no excess risk of endometrial hyperplasia.
Journal ArticleDOI
Effects of Hormone Replacement Therapy on Endometrial Histology in Postmenopausal Women: The Postmenopausal Estrogen/Progestin Interventions (PEPI) Trial
Howard L. Judd,Irma Mebane-Sims,Claudine Legault,Carol Wasilauskas,Susan Johnson,Maria J. Merino,Elizabeth Barrett-Connor,Jose Trabal,Valery T. Miller,Vanessa M. Barnabei,Ginny Levin,Trudy L. Bush,David C. Foster,Howard A. Zacur,J. Donald Woodruff,Marcia L. Stefanick,Peter D. Wood,Allison Akana,W. Leroy Heinrichs,Katherine A. O'Hanlan,Richard P. Buyalos,Gail A. Greendale,Kathy Lozano,Mary Lou Carrion-Petersen,Carmella Cavero,Robert Langer,Helmut G. Schrott,Jo Ann Benda,Charles deProsse,Deborah Fedderson,Susan R. Johnson,Carl J. Pauerstein,Mohammad M. Ahmad,Herbert P. Brown,Robert S. Schenken,Mercedes Rodriguez-Sifuentes,Philip T. Valente,Mark A. Espeland,H.Bradley Wells,Kathy Lane,Irma L. Mebane-Sims,Joseph Kelaghan,Joan McGowan,Judith E. Fradkin,Sheryl S. Sherman,Robert E. Scully +45 more
TL;DR: Combining CEE with cyclic or continuous MPA or cyclic MP protected the endometrium from hyperplastic changes associated with estrogen-only therapy.
Journal ArticleDOI
Rationale, design, and conduct of the PEPI Trial. Postmenopausal Estrogen/Progestin Interventions
Mark A. Espeland,Trudy L. Bush,Irma Mebane-Sims,Marcia L. Stefanick,Susan R. Johnson,Roger Sherwin,Myron A. Waclawiw +6 more
TL;DR: The PEPI trial as mentioned in this paper was designed to test whether estrogen and estrogen-progestin therapy is efficacious in the prevention of cardiovascular disease, as a much larger trial with clinical disease outcomes is needed to answer that question.
Journal ArticleDOI
Rationale, design, and conduct of the PEPI trial
Trudy L. Bush,Irma Mebane-Sims,Marcia L. Stefanick,Susan R. Johnson,Roger Sherwin,Myron A. Waclawiw +5 more
TL;DR: PEPI was not designed to test whether estrogen and estrogen-progestin therapy is efficacious in the prevention of cardiovascular disease, as a much larger trial with clinical disease outcomes is needed to answer that question.