C
Claudine Legault
Researcher at Wake Forest University
Publications - 59
Citations - 8544
Claudine Legault is an academic researcher from Wake Forest University. The author has contributed to research in topics: Randomized controlled trial & Estrogen. The author has an hindex of 31, co-authored 59 publications receiving 8076 citations. Previous affiliations of Claudine Legault include University of Texas Medical Branch & Royal North Shore Hospital.
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Journal ArticleDOI
Effects of Estrogen or Estrogen/ Progestin Regimens on Heart Disease Risk Factors in Postmenopausal Women: The Postmenopausal Estrogen/Progestin Interventions (PEPI) Trial
Valery T. Miller,John C. LaRosa,Vanessa M. Barnabei,Craig M. Kessler,Ginny Levin,Ann Smith-Roth,Margaret Griffin,Diane B. Stoy,Trudy L. Bush,Howard A. Zacur,David A. Foster,Jean Anderson,Alice McKenzie,Susan C. Miller,Peter D. Wood,Marcia L. Stefanick,Robert Marcus,Allison Akana,W. Leroy Heinrichs,Charlene Kirchner,Katherine A. O'Hanlan,Melissa Ruyle,Mary A. Sheehan,Howard L. Judd,Gail A. Greendale,Richard Bayalos,Kathy Lozano,Kathy Kawakami,Elizabeth Barrett-Connor,Robert Langer,Donna Kritz-Silverstein,Mary Lou Carrion-Petersen,Carmela Cavero,Helmut G. Schrott,Susan R. Johnson,Deborah A. Feddersen,Denise L. Krutzfeldt,Jo Ann Benda,Carl J. Pauerstein,Jose Trabal,Robert S. Schenken,Michael P. Stern,Mercedes Rodriguez-Sifuentes,Carann Easton,H B Wells,Mark A. Espeland,George Howard,Robert Byington,Claudine Legault,Sally A. Shumaker,Patricia E. Hogan,Don Hire,Carol Wasilauskas,Margaret K. James,Kathy Lane,Tim Terrell,Stephanie Reece,June J Pierce,Mary Snow,Susan Anthony,Irma Mebane-Sims,Paula T. Einhorn,Sally Hunsberger,Myron A. Waclawiw,Ken Lippel,Diane L. Lucas,Joel Verter,Sherry Jackson,Joseph Kelaghan,Jeffrey M. Perlman,Pam Wolf,Joan McGowan,Stephen Gordon,Stephen Heyse,Judith E. Fradkin,Sherry Sherman,Lot B. Page,Ann Sorenson,Barbara S. Hulka,Baruch A. Brody,Ronald T. Burkman,Robert P. Heaney,Ronald M. Krauss,Harold Roberts,Janet Wittes,Lawrence Riggs,Richard Moss,John J. Albers,Santica M. Marcovina,S. Edwin Fineberg,Russell P. Tracy,Maria J. Merino,Robert E. Scully,Virginia A. LiVolsi,Gerald Kessler +94 more
TL;DR: Estrogen alone or in combination with a progestin improves lipoproteins and lowers fibrinogen levels without detectable effects on postchallenge insulin or blood pressure and in women with a uterus, CEE with cyclic MP has the most favorable effect on HDL-C and no excess risk of endometrial hyperplasia.
Journal ArticleDOI
Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women: the Women's Health Initiative Memory Study: a randomized controlled trial.
Sally A. Shumaker,Claudine Legault,Stephen R. Rapp,Leon J. Thal,Robert B. Wallace,Judith K. Ockene,Susan L. Hendrix,Beverly N. Jones,Annlouise R. Assaf,Rebecca D. Jackson,Jane Morley Kotchen,Sylvia Wassertheil-Smoller,Jean Wactawski-Wende +12 more
TL;DR: Estrogen plus progestin therapy increased the risk for probable dementia in postmenopausal women aged 65 years or older and did not prevent mild cognitive impairment in these women, supporting the conclusion that the risks of estrogen plus progESTin outweigh the benefits.
Journal ArticleDOI
Effect of Postmenopausal Hormones on Inflammation-Sensitive Proteins The Postmenopausal Estrogen/Progestin Interventions (PEPI) Study
Mary Cushman,Claudine Legault,Elizabeth Barrett-Connor,Marcia L. Stefanick,Craig M. Kessler,Howard L. Judd,Pamela A. Sakkinen,Russell P. Tracy +7 more
TL;DR: The Postmenopausal Estrogen/Progestin Interventions Trial, a randomized, placebo-controlled trial of the effects of 4 hormone preparations on cardiovascular disease risk factors, found postmenopausal hormones rapidly increased the concentration of the inflammation factor C-reactive protein.
Journal ArticleDOI
Effects of Intensive Diet and Exercise on Knee Joint Loads, Inflammation, and Clinical Outcomes Among Overweight and Obese Adults With Knee Osteoarthritis: The IDEA Randomized Clinical Trial
Stephen P. Messier,Shannon L. Mihalko,Claudine Legault,Gary D. Miller,Barbara J. Nicklas,Paul DeVita,Daniel P. Beavers,David J. Hunter,Mary F. Lyles,Felix Eckstein,Jeff D. Williamson,J. Jeffery Carr,Ali Guermazi,Richard F. Loeser +13 more
TL;DR: To determine whether a ≥10% reduction in body weight induced by diet, with or without exercise, would improve mechanistic and clinical outcomes more than exercise alone, a single-blind, 18-month, randomized clinical trial was conducted.
Journal ArticleDOI
Effects of Hormone Replacement Therapy on Endometrial Histology in Postmenopausal Women: The Postmenopausal Estrogen/Progestin Interventions (PEPI) Trial
Howard L. Judd,Irma Mebane-Sims,Claudine Legault,Carol Wasilauskas,Susan Johnson,Maria J. Merino,Elizabeth Barrett-Connor,Jose Trabal,Valery T. Miller,Vanessa M. Barnabei,Ginny Levin,Trudy L. Bush,David C. Foster,Howard A. Zacur,J. Donald Woodruff,Marcia L. Stefanick,Peter D. Wood,Allison Akana,W. Leroy Heinrichs,Katherine A. O'Hanlan,Richard P. Buyalos,Gail A. Greendale,Kathy Lozano,Mary Lou Carrion-Petersen,Carmella Cavero,Robert Langer,Helmut G. Schrott,Jo Ann Benda,Charles deProsse,Deborah Fedderson,Susan R. Johnson,Carl J. Pauerstein,Mohammad M. Ahmad,Herbert P. Brown,Robert S. Schenken,Mercedes Rodriguez-Sifuentes,Philip T. Valente,Mark A. Espeland,H.Bradley Wells,Kathy Lane,Irma L. Mebane-Sims,Joseph Kelaghan,Joan McGowan,Judith E. Fradkin,Sheryl S. Sherman,Robert E. Scully +45 more
TL;DR: Combining CEE with cyclic or continuous MPA or cyclic MP protected the endometrium from hyperplastic changes associated with estrogen-only therapy.