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Isabelle Lemasson
Researcher at East Carolina University
Publications - 41
Citations - 1595
Isabelle Lemasson is an academic researcher from East Carolina University. The author has contributed to research in topics: Transcription (biology) & Transcription factor. The author has an hindex of 23, co-authored 38 publications receiving 1451 citations. Previous affiliations of Isabelle Lemasson include Centre national de la recherche scientifique & French Institute of Health and Medical Research.
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Journal ArticleDOI
Human T-Cell Leukemia Virus Type 1 (HTLV-1) bZIP Protein Interacts with the Cellular Transcription Factor CREB To Inhibit HTLV-1 Transcription
Isabelle Lemasson,Matthew R. Lewis,Nicholas Polakowski,Patrick Hivin,Marie-Hélène Cavanagh,Sabine Thébault,Benoit Barbeau,Jennifer K. Nyborg,Jean-Michel Mesnard +8 more
TL;DR: HBZ reduces HTLV-1 transcription and virion production, and the interaction between HBZ and the cellular transcription factor CREB is characterized, suggesting that HBZ may deregulate CREB-dependent cellular gene expression.
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An Interaction between the Human T Cell Leukemia Virus Type 1 Basic Leucine Zipper Factor (HBZ) and the KIX Domain of p300/CBP Contributes to the Down-regulation of Tax-dependent Viral Transcription by HBZ
Isabelle Clerc,Nicholas Polakowski,Charlotte André-Arpin,Charlotte André-Arpin,Pamela R. Cook,Benoit Barbeau,Jean-Michel Mesnard,Jean-Michel Mesnard,Isabelle Lemasson +8 more
TL;DR: This study shows that HBZ binds directly to the p300 and CBP coactivators, and provides evidence that this interaction interferes with the ability of Tax to bind p300/CBP and thereby inhibits the association of the coactivator with the viral promoter.
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Binding of p53 to the KIX Domain of CREB Binding Protein A POTENTIAL LINK TO HUMAN T-CELL LEUKEMIA VIRUS, TYPE I-ASSOCIATED LEUKEMOGENESIS
TL;DR: This report identifies the KIX domain as a new p53 contact point on CBP and demonstrates that the activation domain of p53 participates in KIX binding and provides evidence showing that this interaction is critical for p53 transactivation function.
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CREB-2, a Cellular CRE-Dependent Transcription Repressor, Functions in Association with Tax as an Activator of the Human T-Cell Leukemia Virus Type 1 Promoter
Frédéric Gachon,Annick Peleraux,Sabine Thébault,Joelle Dick,Isabelle Lemasson,Christian Devaux,Jean-Michel Mesnard +6 more
TL;DR: It is demonstrated that CREB-2 cooperates with Tax to enhance viral transcription and that its basic-leucine zipper C-terminal domain is required for both in vitro and in vivo interactions with Tax.
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p53 recruitment of CREB binding protein mediated through phosphorylated CREB: a novel pathway of tumor suppressor regulation.
TL;DR: It is proposed that phosphorylated CREB mediates recruitment of CBP to p53-responsive promoters through direct interaction with p53, providing evidence for a novel pathway that integrates cAMP signaling and p53 transcriptional activity.