P
Patrick Hivin
Researcher at Centre national de la recherche scientifique
Publications - 8
Citations - 713
Patrick Hivin is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: Transcription (biology) & Transcription factor. The author has an hindex of 8, co-authored 8 publications receiving 671 citations. Previous affiliations of Patrick Hivin include University of Montpellier.
Papers
More filters
Journal ArticleDOI
Human T-Cell Leukemia Virus Type 1 (HTLV-1) bZIP Protein Interacts with the Cellular Transcription Factor CREB To Inhibit HTLV-1 Transcription
Isabelle Lemasson,Matthew R. Lewis,Nicholas Polakowski,Patrick Hivin,Marie-Hélène Cavanagh,Sabine Thébault,Benoit Barbeau,Jennifer K. Nyborg,Jean-Michel Mesnard +8 more
TL;DR: HBZ reduces HTLV-1 transcription and virion production, and the interaction between HBZ and the cellular transcription factor CREB is characterized, suggesting that HBZ may deregulate CREB-dependent cellular gene expression.
Journal ArticleDOI
HTLV-I antisense transcripts initiating in the 3'LTR are alternatively spliced and polyadenylated
Marie-Hélène Cavanagh,Sébastien Landry,Brigitte Audet,Charlotte Arpin-André,Patrick Hivin,Marie-Ève Paré,Julien Thête,Eric Wattel,Susan J. Marriott,Jean-Michel Mesnard,Benoit Barbeau,Benoit Barbeau +11 more
TL;DR: It is shown that HBZ-encoding transcripts initiate in the 3' long terminal repeat (LTR) at several positions and consist of two alternatively spliced variants (SP1 and SP2), which conclusively demonstrate the existence of antisense transcription in retroviruses.
Journal ArticleDOI
HBZ interacts with JunD and stimulates its transcriptional activity.
TL;DR: It is shown that HBZ can activate JunD‐dependent transcription and that its amino‐terminus is required, and that this association occurs via the bZIP domain of the two proteins.
Journal ArticleDOI
Nuclear localization of HTLV-I bZIP factor (HBZ) is mediated by three distinct motifs
Patrick Hivin,Mélissa Frédéric,Charlotte Arpin-André,Jihane Basbous,Sabine Thébault,Jean-Michel Mesnard +5 more
TL;DR: It is reported here that the nuclear targeting of HBZ is mediated by three distinct nuclear localization signals and that at least two are necessary for the translocation ofHBZ to the nucleus.
Journal ArticleDOI
The HBZ-SP1 isoform of human T-cell leukemia virus type I represses JunB activity by sequestration into nuclear bodies
Patrick Hivin,Jihane Basbous,Frédéric Raymond,Daniel Henaff,Charlotte Arpin-André,Véronique Robert-Hebmann,Benoit Barbeau,Jean-Michel Mesnard +7 more
TL;DR: HBZ-mediated sequestration of JunB to the HBZ-NBs may be causing the repression of Jun B activity in vivo, and it is suggested that HBZ needs cellular partners, including bZIP factors, to form HBZ -NBs.