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Isabelle Schiffer
Researcher at Max Planck Society
Publications - 4
Citations - 54
Isabelle Schiffer is an academic researcher from Max Planck Society. The author has contributed to research in topics: TFEB & Proteotoxicity. The author has an hindex of 2, co-authored 4 publications receiving 17 citations. Previous affiliations of Isabelle Schiffer include University of Cologne.
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Journal ArticleDOI
NFYB-1 regulates mitochondrial function and longevity via lysosomal prosaposin
Rebecca George Tharyan,Andrea Annibal,Isabelle Schiffer,Isabelle Schiffer,Raymond Laboy,Raymond Laboy,Ilian Atanassov,Anna Luise Weber,Birgit Gerisch,Adam Antebi,Adam Antebi +10 more
TL;DR: It is suggested that the NFYB-1–prosaposin axis coordinates lysosomal to mitochondria signalling via lipid pools to enhance cellular mitochondrial function and organismal health.
Journal ArticleDOI
Hexosamine Pathway Activation Improves Protein Homeostasis through the Integrated Stress Response
Moritz Horn,Sarah I. Denzel,Balaji Srinivasan,K. Allmeroth,Isabelle Schiffer,Vignesh Karthikaisamy,Stephan Miethe,Peter Breuer,Adam Antebi,Adam Antebi,Martin S. Denzel,Martin S. Denzel +11 more
TL;DR: The HP has a conserved role in improving protein quality control through modulation of the integrated stress response (ISR) and co-overexpression of gfat-1 and proteotoxic polyQ peptides in muscles reveals a strong protective cell-autonomous role of the HP.
Journal ArticleDOI
miR-1 coordinately regulates lysosomal v-ATPase and biogenesis to impact proteotoxicity and muscle function during aging.
Isabelle Schiffer,Birgit Gerisch,Kazuto Kawamura,Raymond Laboy,Jennifer E. Hewitt,Jennifer E. Hewitt,Martin S. Denzel,Martin S. Denzel,Marcelo A. Mori,Siva A. Vanapalli,Yidong Shen,Orsolya Symmons,Adam Antebi,Adam Antebi +13 more
TL;DR: In this article, the conserved muscle-enriched microRNA, miR-1, regulates distinct aspects of muscle development, but whether it plays a role during aging is unknown.
Posted ContentDOI
miR-1 coordinately regulates lysosomal v-ATPase and biogenesis to affect muscle contractility upon proteotoxic challenge during ageing
Isabelle Schiffer,Birgit Gerisch,Kazuto Kawamura,Raymond Laboy,Jennifer E. Hewitt,Jennifer E. Hewitt,Martin S. Denzel,Martin S. Denzel,Marcelo A. Mori,Siva A. Vanapalli,Yongyi Shen,Orsolya Symmons,Adam Antebi,Adam Antebi +13 more
TL;DR: In this paper, the role of C. elegans miR-1 in muscle function in response to proteostatic stress during adulthood was investigated and it was shown that miR1 coordinately regulates v-ATPase and biogenesis to impact muscle function and health during ageing.