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Isao Naguro
Researcher at University of Tokyo
Publications - 65
Citations - 2752
Isao Naguro is an academic researcher from University of Tokyo. The author has contributed to research in topics: ASK1 & Kinase. The author has an hindex of 26, co-authored 56 publications receiving 2135 citations.
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Journal ArticleDOI
Iron homeostasis and iron-regulated ROS in cell death, senescence and human diseases
TL;DR: Understanding the spatiotemporal availability of iron and the role of iron in generating ROS will provide clues for the suppression of ROS and cytotoxic redox-active iron and enable us to find novel therapeutic targets for various diseases.
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Apoptosis signal-regulating kinase 1 in stress and immune response.
TL;DR: The molecular mechanisms by which ASK1 functions in stress and immune responses are focused on and the possible involvement of AsK1 in human diseases is discussed.
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The roles of ASK family proteins in stress responses and diseases.
TL;DR: This review summarizes the recent findings on ASK family proteins and their implications in various diseases and describes its oxidative stress-dependent activation.
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Requirement of Reactive Oxygen Species-dependent Activation of ASK1-p38 MAPK Pathway for Extracellular ATP-induced Apoptosis in Macrophage
Takuya Noguchi,Ken Ishii,Hisashi Fukutomi,Isao Naguro,Atsushi Matsuzawa,Kohsuke Takeda,Hidenori Ichijo +6 more
TL;DR: It is shown that activation of p38 mitogen-activated protein kinase (MAPK) plays a critical role in ATP-induced apoptosis, and ROS-mediated activation of the ASK1-p38 MAPK pathway downstream of P2X7 receptor is required for ATP- induced apoptosis in macrophages.
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The aspartyl protease DDI2 activates Nrf1 to compensate for proteasome dysfunction.
Shun Koizumi,Taro Irie,Shoshiro Hirayama,Yasuyuki Sakurai,Hideki Yashiroda,Isao Naguro,Hidenori Ichijo,Jun Hamazaki,Shigeo Murata +8 more
TL;DR: It is shown that the aspartyl protease DNA-damage inducible 1 homolog 2 (DDI2) is required to cleave and activate Nrf1, and this results provide a clue for blocking compensatory proteasome synthesis to improve cancer therapies targeting proteasomes.