Isao Tawara

TL;DR: Kinetic analysis showed that the administration of anti-CD25 mAb (PC61) later than day 2 after tumor inoculation caused no tumor regression, irrespective of depletion of CD4+ CD25+ immunoregulatory cells.

TL;DR: It is proposed that SEREX identifies a pool of autoantigens that maintains and regulates immunological homeostasis via CD4+ CD25+ regulatory T cells.

TL;DR: It is proposed that antigen delivery through the S. typhimurium type III secretion system is a promising novel strategy for cancer vaccine development.

TL;DR: The number of CD4(+)CD25(+) T cells was significantly lower in the ITP patients in the severe phase, and in patients positive for anti-glycoprotein IIb-IIIa antibody, however, the number of those cells increased in the patients at the complete remission phase, especially after a splenectomy.

TL;DR: In this article, the authors defined a series of broadly expressed self-antigens derived from chemically induced mouse sarcomas by serological identification of antigens by recombinant expression cloning (SEREX).