J
Jorge E. Galán
Researcher at Yale University
Publications - 222
Citations - 37024
Jorge E. Galán is an academic researcher from Yale University. The author has contributed to research in topics: Secretion & Effector. The author has an hindex of 102, co-authored 221 publications receiving 34982 citations. Previous affiliations of Jorge E. Galán include State University of New York System & Teikyo University.
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Journal ArticleDOI
Type III Secretion Machines: Bacterial Devices for Protein Delivery into Host Cells
Jorge E. Galán,Alan Collmer +1 more
TL;DR: Several Gram-negative pathogenic bacteria have evolved a complex protein secretion system termed type III to deliver bacterial effector proteins into host cells that then modulate host cellular functions.
Journal ArticleDOI
Protein delivery into eukaryotic cells by type III secretion machines
Jorge E. Galán,Hans Wolf-Watz +1 more
TL;DR: A bacterial organelle that has specifically evolved to deliver bacterial proteins into eukaryotic cells is encoded by a large number of bacterial species that are symbiotic or pathogenic for humans, other animals including insects or nematodes, and plants.
Journal ArticleDOI
Cloning and molecular characterization of genes whose products allow Salmonella typhimurium to penetrate tissue culture cells.
Jorge E. Galán,rd R Curtiss +1 more
TL;DR: Using an in vitro system, a genetic locus is isolated that confers to a noninvasive strain of Salmonella typhimurium the ability to penetrate tissue culture cells and show decreased ability to colonize the Peyer's patches, the small intestinal wall, and the spleen when administered perorally and intraperitoneally.
Journal ArticleDOI
Amplification of an invA gene sequence of Salmonella typhimurium by polymerase chain reaction as a specific method of detection of Salmonella.
K. Rahn,S.A. De Grandis,R. C. Clarke,Scott A. McEwen,Jorge E. Galán,C C Ginocchio,rd R Curtiss,Carlton L. Gyles +7 more
TL;DR: The detection of 99.4% of Salmonella strains tested and the failure to specifically amplify DNA from non-Salmonellastrains confirm that the invA gene contains sequences unique to Salmoneella and demonstrate that this gene is a suitable PCR target, with potential diagnostic applications.
Journal ArticleDOI
Supramolecular structure of the Salmonella typhimurium type III protein secretion system.
Tomoko Kubori,Yukiyasu Matsushima,Yukiyasu Matsushima,Dai Nakamura,Dai Nakamura,Jaimol Uralil,Jaimol Uralil,Maria Lara-Tejero,Maria Lara-Tejero,Anand Sukhan,Anand Sukhan,Jorge E. Galán,Jorge E. Galán,Shin-Ichi Aizawa,Shin-Ichi Aizawa +14 more
TL;DR: Electron microscopy revealed supramolecular structures spanning the inner and outer membranes of flagellated and nonflagllated strains; such structures were not detected in strains carrying null mutations in components of the type III apparatus.