Li-Mei Chen

TL;DR: Using consensus degenerate RT-PCR, a novel influenza A virus is identified in a flat-faced fruit bat from Peru, indicating that bats constitute a potentially important and likely ancient reservoir for a diverse pool of influenza viruses.

TL;DR: Despite its divergence from known influenza A virus, the bat virus is compatible for genetic exchange with human influenza viruses in human cells, suggesting the potential capability for reassortment and contributions to new pandemic or panzootic influenza A viruses.

TL;DR: This work shows that SopE, a substrate of this secretion system, stimulates cytoskeletal reorganization and JNK activation in a CDC42- and Rac-1-dependent manner, and establishes a paradigm for microbial stimulation of cellular responses in which the pathogen induces signaling events by directly engaging the signaling machinery within the host cell.

TL;DR: The geographic expansion of the infection and its persistence for several years indicate efficient transmission of canine influenza virus among greyhounds, and evidence of infection in pet dogs suggests that this infection may also become enzootic in this population.

TL;DR: The results demonstrate the general equivalence of mouse and ferret models for assessment of the virulence of 2003 and 2004 H5N1 viruses, however, the apparent enhancement ofvirulence of these viruses in humans in 2004 was better reflected in the ferret.