M
Mitchell Kronenberg
Researcher at La Jolla Institute for Allergy and Immunology
Publications - 289
Citations - 22825
Mitchell Kronenberg is an academic researcher from La Jolla Institute for Allergy and Immunology. The author has contributed to research in topics: Natural killer T cell & Antigen. The author has an hindex of 82, co-authored 275 publications receiving 21348 citations. Previous affiliations of Mitchell Kronenberg include University of California, San Diego.
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Journal ArticleDOI
The natural killer T-cell ligand alpha-galactosylceramide prevents autoimmune diabetes in non-obese diabetic mice.
Seokmann Hong,Michael T. Wilson,Isao Serizawa,Lan Wu,Nagendra Singh,Olga V. Naidenko,Toru Miura,Tomoku Haba,David C. Scherer,Jie Wei,Mitchell Kronenberg,Yasuhiko Koezuka,Luc Van Kaer +12 more
TL;DR: It is shown that α-GalCer prevents development of diabetes in wild-type but not CD1d-deficient NOD mice, and this findings indicate thatα- GalCer might be useful for therapeutic intervention in human diseases characterized by Th1-mediated pathology such as Type 1 diabetes.
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Prolonged IFN-gamma-producing NKT response induced with alpha-galactosylceramide-loaded DCs.
TL;DR: Natural killer T (NKT) lymphocytes mediate a rapid reaction to the glycolipid drug α-galactosylceramide (αGalCer), which triggers release of large amounts of cytokines into the serum within 12 h, starting with interleukin 4 (IL-4).
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Impact of Genetic Polymorphisms on Human Immune Cell Gene Expression.
Benjamin J Schmiedel,Divya Singh,Ariel Madrigal,Alan G. Valdovino-Gonzalez,Brandie White,Jose Zapardiel-Gonzalo,Brendan Ha,Gökmen Altay,Jason A. Greenbaum,Graham McVicker,Grégory Seumois,Anjana Rao,Mitchell Kronenberg,Bjoern Peters,Pandurangan Vijayanand,Pandurangan Vijayanand,Pandurangan Vijayanand +16 more
TL;DR: The DICE project identified cis-eQTLs for a total of 12,254 unique genes, which represent 61% of all protein-coding genes expressed in these cell types and found that biological sex is associated with major differences in immune cell gene expression in a highly cell-specific manner.
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The unique role of natural killer T cells in the response to microorganisms
TL;DR: Natural killer T (NKT) cells combine features of the innate and adaptive immune systems and respond to innate cytokines produced by dendritic cells that have been activated by microbes.
Journal ArticleDOI
NKT cells derive from double-positive thymocytes that are positively selected by CD1d
Laurent Gapin,Jennifer L. Matsuda,Jennifer L. Matsuda,Charles D. Surh,Mitchell Kronenberg,Mitchell Kronenberg +5 more
TL;DR: It is shown here that immature double-positive (DP) thymocytes form the canonical rearranged Vα gene of NKT cells at nearly equivalent frequencies in the presence or absence of CD1d expression, confirming the existence of a DP intermediate forCD1d-reactive N KT cells.