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Ishan Capila
Researcher at Massachusetts Institute of Technology
Publications - 61
Citations - 5515
Ishan Capila is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Heparin & Heparan sulfate. The author has an hindex of 25, co-authored 60 publications receiving 5131 citations. Previous affiliations of Ishan Capila include University of Iowa & University of California, San Francisco.
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Journal ArticleDOI
Heparin-protein interactions
Ishan Capila,Robert J. Linhardt +1 more
TL;DR: This review focuses on aspects of heparin structure and conformation, which are important for its interactions with proteins, and describes the interaction ofheparin and heparan sulfate with selected families of heParin-binding proteins.
Journal ArticleDOI
Temporal targeting of tumour cells and neovasculature with a nanoscale delivery system
Shiladitya Sengupta,David A. Eavarone,Ishan Capila,Ganlin Zhao,Nicki Watson,Tanyel Kiziltepe,Ram Sasisekharan +6 more
TL;DR: The disease-driven engineering of a drug delivery system, a ‘nanocell’, which overcomes barriers unique to solid tumours and results in improved therapeutic index with reduced toxicity, enabling the model of an ‘integrative’ approach in cancer therapy.
Journal ArticleDOI
Oversulfated chondroitin sulfate is a contaminant in heparin associated with adverse clinical events.
Marco Guerrini,Daniela Beccati,Zachary Shriver,Annamaria Naggi,Karthik Viswanathan,Antonella Bisio,Ishan Capila,Jonathan C. Lansing,Sara Guglieri,Blair A. Fraser,Ali Al-Hakim,Nur Sibel Gunay,Zhenqing Zhang,Luke Robinson,Lucinda F. Buhse,Moheb Nasr,Janet Woodcock,Robert Langer,Ganesh Venkataraman,Robert J. Linhardt,Benito Casu,Giangiacomo Torri,Ram Sasisekharan +22 more
TL;DR: Through detailed structural analysis, the contaminant was found to contain a disaccharide repeat unit of glucuronic acid linked β1→3 to a β-N-acetylgalactosamine, indicative of an allergic-type reaction.
Journal ArticleDOI
Heparin—Protein Interactions
Ishan Capila,Robert J. Linhardt +1 more
TL;DR: Heparin and the structurally related heparan sulfated polysaccharide are complex linear polymers comprised of a mixture of chains of different length, having variable sequences.
Book ChapterDOI
Heparin and heparan sulfate: analyzing structure and microheterogeneity.
TL;DR: This chapter provides an overview of the origin of the structural microheterogeneity observed in heparin and heparan sulfate, and the orthogonal analytical methodologies that are required to help decipher this information.