Z
Zhenqing Zhang
Researcher at Rensselaer Polytechnic Institute
Publications - 56
Citations - 2690
Zhenqing Zhang is an academic researcher from Rensselaer Polytechnic Institute. The author has contributed to research in topics: Heparin & Medicine. The author has an hindex of 26, co-authored 44 publications receiving 2495 citations. Previous affiliations of Zhenqing Zhang include Baxter International & Soochow University (Suzhou).
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Oversulfated chondroitin sulfate is a contaminant in heparin associated with adverse clinical events.
Marco Guerrini,Daniela Beccati,Zachary Shriver,Annamaria Naggi,Karthik Viswanathan,Antonella Bisio,Ishan Capila,Jonathan C. Lansing,Sara Guglieri,Blair A. Fraser,Ali Al-Hakim,Nur Sibel Gunay,Zhenqing Zhang,Luke Robinson,Lucinda F. Buhse,Moheb Nasr,Janet Woodcock,Robert Langer,Ganesh Venkataraman,Robert J. Linhardt,Benito Casu,Giangiacomo Torri,Ram Sasisekharan +22 more
TL;DR: Through detailed structural analysis, the contaminant was found to contain a disaccharide repeat unit of glucuronic acid linked β1→3 to a β-N-acetylgalactosamine, indicative of an allergic-type reaction.
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Lessons learned from the contamination of heparin
TL;DR: The heparin contamination crisis, its resolution, and the lessons learned are reviewed, with the conclusion that safer and better-regulated processes are needed for heparIn production.
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Solution structures of chemoenzymatically synthesized heparin and its precursors
Zhenqing Zhang,Scott A. McCallum,Jin Xie,Lidia Nieto,Francisco Corzana,Jesús Jiménez-Barbero,Miao Chen,Jian Liu,Robert J. Linhardt +8 more
TL;DR: Stable isotope-labeled Heparin was indistinguishable from heparin derived from animal tissues and is a novel reagent for studying the interaction of hepar in with proteins.
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Complete monosaccharide analysis by high-performance anion-exchange chromatography with pulsed amperometric detection.
TL;DR: A high-performance anion-exchange chromatography method with pulsed amperometric detection was initially developed to analyze acidic sugars including different uronic acids and sialic acids, and a method to profile complete monosaccharides, including most neutral, amino, and acidic sugars, was developed.
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Orthogonal analytical approaches to detect potential contaminants in heparin
Marco Guerrini,Zhenqing Zhang,Zachary Shriver,Annamaria Naggi,Sayaka Masuko,Robert Langer,Benito Casu,Robert J. Linhardt,Giangiacomo Torri,Ram Sasisekharan +9 more
TL;DR: It is shown that given the complexity of heparin samples, and the requirement to ensure their purity and safety, use of orthogonal analytical techniques is effective at detecting an array of potential contaminants that could be present.