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Ismail A. Abdelhamid

Bio: Ismail A. Abdelhamid is an academic researcher from Cairo University. The author has contributed to research in topics: Chemistry & Pyrazole. The author has an hindex of 23, co-authored 149 publications receiving 1414 citations. Previous affiliations of Ismail A. Abdelhamid include Leibniz University of Hanover & Kuwait University.


Papers
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Journal ArticleDOI
TL;DR: Three heteroaryl pyrazole derivatives were synthesized and reacted with chitosan to form Schiff bases of chitOSan and indicated that the antimicrobial activity was dependent on the type of the Schiff base moiety.

67 citations

Journal ArticleDOI
TL;DR: In this article, the synthesis and utilization of enamines as precursors for heterocyclic and carbocycic compounds are reviewed. And two general synthetic routes for preparation of enamine based on condensation and addition reactions are discussed.
Abstract: Recent synthesis and utilization of enamines as precursors for heterocyclic and carbocyclic compounds are reviewed. Two general synthetic routes for preparation of enamines based on condensation and addition reactions. Enamines and azaenamines can be used as building blocks for carbocyclic, five-and six-membered heterocyclic as well as fused heterocyclic compounds.

55 citations

Journal ArticleDOI
TL;DR: An efficient route for the synthesis of novel bis(1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile) derivatives is reported and indicated the best binding mode compared to the standard ligand sorafenib.

53 citations

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TL;DR: Two novel series of cyclic 2‐oxindole derivatives incorporating 2‐amino‐tetrahydroquinolin‐5‐one and 15b showed apoptotic inhibition of the proliferation of human breast adenocarcinoma MCF‐7 cells through DNA fragmentation and the inhibition of angiogenesis by decreasing vascular endothelial growth factor expression and secretion.
Abstract: A novel series of cyclic 2-oxindole derivatives incorporating 2-amino-tetrahydroquinolin-5-one were prepared. The structures of the prepared compounds were elucidated using different spectral tools. The regio-orientation of the reaction products was elucidated through NOE difference experiments and through using substituents on the ortho position to affect further cyclization. Antitumor and antimicrobial evaluations were performed on the prepared compounds. Most of these compounds exhibited high to moderate antimicrobial activity. With respect to the antitumor activity, the compounds showed more potent cytotoxic effect only toward the human breast cancer cell line MCF-7. Also, we found that derivatives containing an ester group (8c, 11b, 14b, and 15b) are more active than those containing a cyanide group (8a, 11a, 14a, and 15a). Moreover, compounds 15b and 8b are the most active derivatives in this group. These two compounds showed apoptotic inhibition of the proliferation of human breast adenocarcinoma MCF-7 cells through DNA fragmentation, induction of the tumor suppressor protein p53, induction of caspase-9, and finally the inhibition of angiogenesis by decreasing vascular endothelial growth factor expression and secretion.

49 citations

Journal ArticleDOI
TL;DR: An efficient and convenient method for the synthesis of bis(4H-chromene-3 carbonitrile) derivatives by one-pot, multicomponent reaction of bis-aldehydes, malononitrile, and dimedone in the presence of a catalytic amount of piperidine is reported in this paper.

42 citations


Cited by
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[...]

08 Dec 2001-BMJ
TL;DR: There is, I think, something ethereal about i —the square root of minus one, which seems an odd beast at that time—an intruder hovering on the edge of reality.
Abstract: There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality. Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …

33,785 citations

Journal ArticleDOI

7,335 citations

Journal ArticleDOI
TL;DR: Acyclic activated alkenes/ alkynes and Asymmetric Baylis-Hillman Reaction: Earlier Developments 5495.
Abstract: 2. Essential Components: Earlier Developments 5449 2.1. Activated alkenes/alkynes 5450 2.1.1. Acyclic activated alkenes/ alkynes 5450 2.1.2. Cyclic activated alkenes 5451 2.2. Electrophiles 5451 2.3. Catalysts 5452 3. Essential Components: Recent Developments 5452 3.1. Activated Alkenes/Alkynes 5452 3.2. Electrophiles 5460 3.3. Catalysts 5477 4. Asymmetric Baylis-Hillman Reaction: Earlier Developments 5495

752 citations

02 Jun 2016

476 citations

Journal ArticleDOI
TL;DR: Structurally characterize the different phenolic compounds and their metabolic pathways as well as review the most important results regarding these compound and their derivatives in cancer treatment and prevention both in tumor cell lines in vitro, in murine models in vivo and finally some results regarding human trials.
Abstract: Cancer is a worldwide scourge; it's the leading cause of death in developed countries and is increasing in developing countries Mankind has been trying with effort to find better and cheaper treatments with fewer side effects, to reduce the incidence of the disease and its consequent mortality For many years, phenolic compounds have been intensely studied for their antitumor, proapoptotic and antiangiogenic effects In recent years, the usage of these compounds has increased considerably This manuscript intends to structurally characterize the different phenolic compounds (flavonoids, hydroxycinnamates, hydroxybenzoates, coumarins, xanthones, chalcones, stilbenes, lignins and lignans) and their metabolic pathways as well as review the most important results regarding these compounds and their derivatives in cancer treatment and prevention both in tumor cell lines in vitro, in murine models in vivo and finally some results regarding human trials

235 citations