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István Pelczer
Researcher at Princeton University
Publications - 181
Citations - 4581
István Pelczer is an academic researcher from Princeton University. The author has contributed to research in topics: Nuclear magnetic resonance spectroscopy & Bicyclic molecule. The author has an hindex of 23, co-authored 176 publications receiving 4191 citations. Previous affiliations of István Pelczer include University of Colorado Boulder & Harvard University.
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Journal ArticleDOI
Structural identification of a bacterial quorum-sensing signal containing boron
Xin Chen,Stephan Schauder,Noelle Potier,Alain Van Dorsselaer,István Pelczer,Bonnie L. Bassler,Frederick M. Hughson +6 more
TL;DR: It is suggested that addition of naturally occurring borate to anAI-2 precursor generates active AI-2, and a potential biological role for boron is indicated, an element required by a number of organisms but for unknown reasons.
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Iron-catalysed tritiation of pharmaceuticals
TL;DR: An iron-catalysed method for the direct 3H labelling of pharmaceuticals by hydrogen isotope exchange is described, using tritium gas as the source of the radioisotope.
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Optimized preprocessing of ultra-performance liquid chromatography/mass spectrometry urinary metabolic profiles for improved information recovery.
Kirill Veselkov,Lisa K. Vingara,Perrine Masson,Steven L. Robinette,Elizabeth J. Want,Jia V. Li,Richard H. Barton,Claire Boursier-Neyret,Bernard Walther,Timothy M. D. Ebbels,István Pelczer,Elaine Holmes,John C. Lindon,Jeremy K. Nicholson +13 more
TL;DR: It is demonstrated that the UPLC/MS peak intensities of urine samples should respond linearly to variable sample dilution across the intensity range, and variance-stabilizing transformation and normalization are critical preprocessing steps that can benefit greatly metabolic information recovery from such data sets when widely applied chemometric methods are used.
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Phosphorylation and processing of the quorum-sensing molecule autoinducer-2 in enteric bacteria.
Karina B. Xavier,Stephen T. Miller,Wenyun Lu,Jeong Hwan Kim,Joshua D. Rabinowitz,István Pelczer,Martin F. Semmelhack,Bonnie L. Bassler,Bonnie L. Bassler +8 more
TL;DR: It is shown that following internalization, the kinase LsrK phosphorylates carbon-5 of the open form of DPD, and Phosphorylated DPD binds specifically to the repressor of the lsr operon, LsrR, consistent with P-DPD being the inducer of the LSR operon.
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Tandem action of glycosyltransferases in the maturation of vancomycin and teicoplanin aglycones: novel glycopeptides.
Heather C. Losey,Mark W. Peczuh,Zhong Chen,Ulrike S. Eggert,Steven D Dong,István Pelczer,Daniel Kahne,Christopher T. Walsh +7 more
TL;DR: In this article, genes encoding four glycosyltransferases, GtfB, C, D, E, were subcloned from Amycolatopsis orientalis strains that produce chloroeremomycin or vancomycin (GtfD, E) into Escherichia coli.