Claire Boursier-Neyret

TL;DR: It is demonstrated that the UPLC/MS peak intensities of urine samples should respond linearly to variable sample dilution across the intensity range, and variance-stabilizing transformation and normalization are critical preprocessing steps that can benefit greatly metabolic information recovery from such data sets when widely applied chemometric methods are used.

TL;DR: This study provides an essential baseline for defining the “normal” metabolome and its main sources of variation in healthy volunteers and established reference human metabolome values in a large and well-defined population of French healthy volunteers.

TL;DR: The lipidome in SOD1(G86R) mice, a model of ALS, is surveyed to suggest that GSLs may play a critical role in ALS muscle pathology and could lead to the identification of new therapeutic targets.

TL;DR: Permeability in the duodenum was two to three times lower than the jejunum for all compounds and so the concept of discrete "absorption windows" along the small intestine as suggested from some pharmacokinetic studies may be related to other effects such as pH and/or solubility.

TL;DR: A rapid, selective, sensitive and reproducible liquid chromatographic method with tandem mass spectrometric detection has been developed and validated for the analysis of a new specific bradycardic agent, ivabradine and six potentially active metabolites in human plasma.