Iva Lelios

TL;DR: High‐dimensional cytometry reveals that microglia, several subsets of border‐associated macrophages and dendritic cells coexist in the CNS at steady state and exhibit disease‐specific transformations in the immune microenvironment during aging and in models of Alzheimer’s disease and multiple sclerosis.

TL;DR: It is shown that in both mice and humans, interleukin-34 (IL-34), an alternative ligand for Csf-1 receptor, is produced by keratinocytes in the epidermis and by neurons in the brain.

TL;DR: Results show that transcriptional regulation by Sall1 maintains microglial identity and physiological properties in the CNS and allows microglia-specific manipulation in vivo.

TL;DR: The current means to reliably distinguish between microglia populations are discussed, and which recent advances have helped to make clear definitions between phenotypically similar, yet functionally diverse myeloid cell types are discussed.

TL;DR: It is reported that AMs, in contrast to most other tissue macrophages, were also dependent on transforming growth factor‐&bgr; receptor (TGF‐& bgr;R) signaling, which reveals an additional layer of complexity regarding the guidance cues, which govern the genesis, maturation, and survival of AMs.