Ivan E. Johnson

TL;DR: The Graph Genome Pipeline as discussed by the authors is a graph reference genome implementation that enables read alignment across 2,800 diploid genomes encompassing 12.6 million SNPs and 4.0 million insertions and deletions (indels).

TL;DR: The precisionFDA Truth Challenge V2 aimed to assess the state-of-the-art of variant calling in difficult-to-map regions and the Major Histocompatibility Complex and new methods out-performed the 2016 Truth Challenge winners.

TL;DR: This work presents a graph genome implementation that enables read alignment across 2,800 diploid genomes encompassing 12.6 million SNPs and 4.0 million indels and shows that iterative augmentation of graph genomes yields incremental gains in variant calling accuracy.

TL;DR: In this article, the N-terminal ANTH domains of the CALM, AP180, HIP1R, and yeast Sla2 were found to bind monoubiquitin with micromolar affinity.