F
Fritz J. Sedlazeck
Researcher at Baylor College of Medicine
Publications - 171
Citations - 12273
Fritz J. Sedlazeck is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Genome & Biology. The author has an hindex of 35, co-authored 122 publications receiving 7133 citations. Previous affiliations of Fritz J. Sedlazeck include Medical University of Vienna & Cold Spring Harbor Laboratory.
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Journal ArticleDOI
Phased diploid genome assembly with single-molecule real-time sequencing
Chen-Shan Chin,Paul Peluso,Fritz J. Sedlazeck,Maria Nattestad,Gregory T. Concepcion,Alicia Clum,Christopher Dunn,Ronan C. O'Malley,Rosa Figueroa-Balderas,Abraham Morales-Cruz,Grant R. Cramer,Massimo Delledonne,Chongyuan Luo,Joseph R. Ecker,Dario Cantu,David R. Rank,Michael C. Schatz,Michael C. Schatz +17 more
TL;DR: The open-source FALCON and FALcon-Unzip algorithms are introduced to assemble long-read sequencing data into highly accurate, contiguous, and correctly phased diploid genomes.
Journal ArticleDOI
Accurate detection of complex structural variations using single-molecule sequencing.
Fritz J. Sedlazeck,Philipp Rescheneder,Moritz Smolka,Han Fang,Maria Nattestad,Arndt von Haeseler,Arndt von Haeseler,Michael C. Schatz,Michael C. Schatz +8 more
TL;DR: NGMLR and Sniffles perform highly accurate alignment and structural variation detection from long-read sequencing data and can automatically filter false events and operate on low-coverage data, thereby reducing the high costs that have hindered the application of long reads in clinical and research settings.
Journal ArticleDOI
GenomeScope: fast reference-free genome profiling from short reads
Gregory Vurture,Fritz J. Sedlazeck,Maria Nattestad,Charles J Underwood,Han Fang,Han Fang,James Gurtowski,Michael C. Schatz,Michael C. Schatz +8 more
TL;DR: GenomeScope is an open‐source web tool to rapidly estimate the overall characteristics of a genome, including genome size, heterozygosity rate and repeat content from unprocessed short reads, which are essential for studying genome evolution.
Journal ArticleDOI
Accurate circular consensus long-read sequencing improves variant detection and assembly of a human genome.
Aaron M. Wenger,Paul Peluso,William J Rowell,Pi-Chuan Chang,Richard Hall,Gregory T. Concepcion,Jana Ebler,Arkarachai Fungtammasan,Alexander Kolesnikov,Nathan D. Olson,Armin Töpfer,Michael Alonge,Medhat Mahmoud,Yufeng Qian,Chen-Shan Chin,Adam M. Phillippy,Michael C. Schatz,Gene Myers,Mark A. DePristo,Jue Ruan,Tobias Marschall,Tobias Marschall,Fritz J. Sedlazeck,Justin M. Zook,Heng Li,Sergey Koren,Andrew Carroll,David R. Rank,Michael W. Hunkapiller +28 more
TL;DR: The optimization of circular consensus sequencing (CCS) is reported to improve the accuracy of single-molecule real-time (SMRT) sequencing (PacBio) and generate highly accurate (99.8%) long high-fidelity (HiFi) reads with an average length of 13.5 kilobases (kb).
Journal ArticleDOI
The pineapple genome and the evolution of CAM photosynthesis
Ray Ming,Ray Ming,Robert VanBuren,Robert VanBuren,Robert VanBuren,Ching Man Wai,Ching Man Wai,Haibao Tang,Haibao Tang,Michael C. Schatz,John E. Bowers,Eric Lyons,Ming Li Wang,Jung Chen,Eric Biggers,Jisen Zhang,Lixian Huang,Lingmao Zhang,Wenjing Miao,Jian Zhang,Zhangyao Ye,Chenyong Miao,Zhicong Lin,Hao Wang,Hongye Zhou,Won Cheol Yim,Henry D. Priest,Chunfang Zheng,Margaret R. Woodhouse,Patrick P. Edger,Romain Guyot,Hao-Bo Guo,Hong Guo,Guangyong Zheng,Ratnesh Singh,Anupma Sharma,Xiang Jia Min,Yun Zheng,Hayan Lee,James Gurtowski,Fritz J. Sedlazeck,Alex Harkess,Michael R. McKain,Zhenyang Liao,Jingping Fang,Juan Liu,Xiaodan Zhang,Qing Zhang,Weichang Hu,Yuan Qin,Kai Wang,Li Yu Chen,Neil J. Shirley,Yann-Rong Lin,Li Yu Liu,Alvaro G. Hernandez,Chris L. Wright,Vincent Bulone,Gerald A. Tuskan,Katy D. Heath,Francis Zee,Paul H. Moore,Ramanjulu Sunkar,Jim Leebens-Mack,Todd C. Mockler,Jeffrey L. Bennetzen,Michael Freeling,David Sankoff,Andrew H. Paterson,Xin-Guang Zhu,Xiaohan Yang,J. Andrew C. Smith,John C. Cushman,Robert E. Paull,Qingyi Yu +74 more
TL;DR: The pineapple lineage has transitioned from C3 photosynthesis to CAM, with CAM-related genes exhibiting a diel expression pattern in photosynthetic tissues, providing the first cis-regulatory link between CAM and circadian clock regulation.