Maria C. Suciu

TL;DR: It is demonstrated that each constituent enhancer seems to act independently and in an additive fashion with respect to hematological phenotype, gene expression, chromatin structure and chromosome conformation, without clear evidence of synergistic or higher-order effects.

TL;DR: It is found that the LRF/ZBTB7A transcription factor occupies fetal γ-globin genes and maintains the nucleosome density necessary for γ -globin gene silencing in adults, and that LRF confers its repressive activity through a NuRD repressor complex independent of the fetal globin repressor BCL11A.

TL;DR: The Graph Genome Pipeline as discussed by the authors is a graph reference genome implementation that enables read alignment across 2,800 diploid genomes encompassing 12.6 million SNPs and 4.0 million insertions and deletions (indels).

TL;DR: The role of the placental-specific transcript of IGF-II (Igf2P0), a major regulator of placental transport capacity in mice, in adapting placental phenotype to UN is determined and deleted altered maternal concentrations of hormones and metabolites in both nutritional states.

TL;DR: The hepcidin-chromatin locus displays HDAC3-mediated reversible epigenetic modifications during both erythropoiesis and iron deficiency, which concludes that suppression of hePCidin expression involves epigenetic regulation by histone deacetylase 3.