L
Li Tai Fang
Researcher at Hoffmann-La Roche
Publications - 33
Citations - 808
Li Tai Fang is an academic researcher from Hoffmann-La Roche. The author has contributed to research in topics: Gene & Germline mutation. The author has an hindex of 14, co-authored 30 publications receiving 601 citations. Previous affiliations of Li Tai Fang include University of California, Los Angeles & University of California, San Francisco.
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Journal ArticleDOI
Effects of Salt Concentrations and Bending Energy on the Extent of Ejection of Phage Genomes
Alex Evilevitch,Li Tai Fang,Aron M. Yoffe,Martin Castelnovo,Donald C. Rau,V. Adrian Parsegian,William M. Gelbart,Charles M. Knobler +7 more
TL;DR: The effects of ambient salts on the pressures inside phage-lambda, for the cases of mono-, di-, and tetravalent cations, are investigated, and it is predicted that the bending energy makes the d-spacings inside the capsid larger than those for bulk DNA at the same osmotic pressure.
Journal ArticleDOI
An ensemble approach to accurately detect somatic mutations using SomaticSeq
Li Tai Fang,Pegah Tootoonchi Afshar,Aparna Chhibber,Marghoob Mohiyuddin,Yu Fan,John C. Mu,Greg Gibeling,Sharon Y. Barr,Narges Bani Asadi,Mark Gerstein,Daniel C. Koboldt,Wenyi Wang,Wing Hung Wong,Hugo Y. K. Lam +13 more
TL;DR: SomaticSeq is an accurate somatic mutation detection pipeline implementing a stochastic boosting algorithm to produce highly accurate somatics mutation calls for both single nucleotide variants and small insertions and deletions that achieves better overall accuracy than any individual tool incorporated.
Journal ArticleDOI
Salt-dependent DNA-DNA spacings in intact bacteriophage λ reflect relative importance of DNA self-repulsion and bending energies.
Xiangyun Qiu,Donald C. Rau,V. Adrian Parsegian,Li Tai Fang,Charles M. Knobler,William M. Gelbart +5 more
TL;DR: From the decrease in d spacings with increasing salt, the relative contributions of DNA self-repulsion and bending to the energetics of packaged phage genomes are deduced.
Posted ContentDOI
precisionFDA Truth Challenge V2: Calling variants from short- and long-reads in difficult-to-map regions
Nathan D. Olson,Justin Wagner,Jennifer McDaniel,Sarah H. Stephens,Samuel T. Westreich,Anish G. Prasanna,Elaine Johanson,Ezekiel J. Maier,Emily Boja,Omar Serang,David Jáspez,José M. Lorenzo-Salazar,Adrián Muñoz-Barrera,Luis A. Rubio-Rodríguez,Carlos Flores,Konstantinos Kyriakidis,Konstantinos Kyriakidis,Andigoni Malousi,Andigoni Malousi,Kishwar Shafin,Trevor Pesout,Miten Jain,Benedict Paten,Pi-Chuan Chang,Alexey Kolesnikov,Maria Nattestad,Gunjan Baid,Sidharth Goel,Howard Yang,Andrew Carroll,Robert Eveleigh,Mathieu Bourgey,Guillaume Bourque,Gen Li,ChouXian Ma,LinQi Tang,YuanPing Du,ShaoWei Zhang,Jordi Morata,Raul Tonda,Genís Parra,Jean-Rémi Trotta,Christian Brueffer,Sinem Demirkaya-Budak,Duygu Kabakci-Zorlu,Deniz Turgut,Özem Kalay,Gungor Budak,Kübra Narcı,Elif Arslan,Richard J. C. Brown,Ivan E. Johnson,Alexey Dolgoborodov,Vladimir Semenyuk,Amit Jain,H. Serhat Tetikol,Varun Jain,Mike Ruehle,Bryan R. Lajoie,Cooper Roddey,Severine Catreux,Rami Mehio,Mian Umair Ahsan,Qian Liu,Kai Wang,Kai Wang,Sayed Mohammad Ebrahim Sahraeian,Li Tai Fang,Marghoob Mohiyuddin,Calvin Hung,Chirag Jain,Hanying Feng,Zhipan Li,Luoqi Chen,Fritz J. Sedlazeck,Justin M. Zook +75 more
TL;DR: The precisionFDA Truth Challenge V2 aimed to assess the state-of-the-art of variant calling in difficult-to-map regions and the Major Histocompatibility Complex and new methods out-performed the 2016 Truth Challenge winners.
Journal ArticleDOI
Gremlin is Overexpressed in Lung Adenocarcinoma and Increases Cell Growth and Proliferation in Normal Lung Cells
Michael S. Mulvihill,Yong-Won Kwon,Sharon Lee,Li Tai Fang,Helen Choi,Roshni Ray,Hio Chung Kang,Jian-Hua Mao,David M. Jablons,Il-Jin Kim +9 more
TL;DR: The data suggest that Gremlin acts in an oncogenic manner in lung adenocarcinoma and could hold promise as a new diagnostic marker or potential therapeutic target in lung AD or general thoracic malignancies.