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Ivan Timofeev
Researcher at University of Cambridge
Publications - 70
Citations - 3462
Ivan Timofeev is an academic researcher from University of Cambridge. The author has contributed to research in topics: Traumatic brain injury & Decompressive craniectomy. The author has an hindex of 26, co-authored 60 publications receiving 2853 citations.
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Journal ArticleDOI
Cerebral extracellular chemistry and outcome following traumatic brain injury: a microdialysis study of 223 patients
Ivan Timofeev,Keri L.H. Carpenter,Jurgens Nortje,Pippa G. Al-Rawi,M. T. O’Connell,Marek Czosnyka,Peter Smielewski,John D. Pickard,David K. Menon,Peter J. Kirkpatrick,Arun K. Gupta,Peter J. Hutchinson +11 more
TL;DR: The results of this study suggest that extracellular metabolic markers are independently associated with outcome following traumatic brain injury and whether treatment-related improvement in biochemistry translates into better outcome remains to be established.
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Consensus statement from the 2014 International Microdialysis Forum
Peter J. Hutchinson,Ibrahim Jalloh,Adel Helmy,Keri L.H. Carpenter,Elham Rostami,Bo Michael Bellander,Martyn G. Boutelle,Jeff W. Chen,Jan Claassen,Claire Dahyot-Fizelier,Per Enblad,Clare N. Gallagher,Raimund Helbok,Lars Hillered,Peter D. Le Roux,Sandra Magnoni,Halinder S. Mangat,David K. Menon,Carl-Henrik Nordström,Kristine O’Phelan,Mauro Oddo,Jon Pérez Bárcena,Claudia S. Robertson,Elisabeth Ronne-Engström,Juan Sahuquillo,Martin D. Smith,Nino Stocchetti,Antonio Belli,T. Adrian Carpenter,Jonathan P. Coles,Marek Czosnyka,Nil Dizdar,J. Clay Goodman,Arun K. Gupta,Troels H. Nielsen,Niklas Marklund,Ambroise Montcriol,M. T. O’Connell,Maria A. Poca,Asita Sarrafzadeh,Richard J. Shannon,Jane Skjøth-Rasmussen,Peter Smielewski,John F. Stover,Ivan Timofeev,Paul M. Vespa,Elizabeth Zavala,Urban Ungerstedt +47 more
TL;DR: A revised and updated consensus statement about the clinical use of microdialysis including technique, data interpretation, relationship with outcome, role in guiding therapy in neurocritical care and research applications is produced.
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The human brain utilizes lactate via the tricarboxylic acid cycle: a 13C-labelled microdialysis and high-resolution nuclear magnetic resonance study.
Clare N. Gallagher,Keri L.H. Carpenter,Peter Grice,Duncan J. Howe,Andrew Mason,Ivan Timofeev,David K. Menon,Peter J. Kirkpatrick,John D. Pickard,Garnette R. Sutherland,Peter J. Hutchinson +10 more
TL;DR: This is the first direct demonstration of brain utilization of lactate as an energy source in humans via the tricarboxylic acid cycle through cerebral microdialysis in patients with traumatic brain injury.
Journal ArticleDOI
Effect of decompressive craniectomy on intracranial pressure and cerebrospinal compensation following traumatic brain injury.
Ivan Timofeev,Marek Czosnyka,Jurgens Nortje,Peter Smielewski,Peter J. Kirkpatrick,Arun K. Gupta,Peter J. Hutchinson +6 more
TL;DR: In this study, decompressive craniectomy led to a sustained reduction in ICP and improvement in cerebral compliance, and derangement in cerebrovascular pressure reactivity requires further studies to evaluate its significance and influence on outcome.
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Continuous monitoring of cerebrovascular pressure reactivity in patients with head injury
Christian Zweifel,Andrea Lavinio,Luzius A. Steiner,Danila K. Radolovich,Peter Smielewski,Ivan Timofeev,M. Hiler,M. Balestreri,Peter J. Kirkpatrick,John D. Pickard,Peter J. Hutchinson,Marek Czosnyka +11 more
TL;DR: The cerebrovascular pressure reactivity index (PRx) showed significant deterioration in refractory intracranial hypertension, was correlated with outcome, and was able to differentiate patients with good outcome, moderate disability, severe disability, and death.