P
Pippa G. Al-Rawi
Researcher at University of Cambridge
Publications - 57
Citations - 3955
Pippa G. Al-Rawi is an academic researcher from University of Cambridge. The author has contributed to research in topics: Microdialysis & Cerebral perfusion pressure. The author has an hindex of 35, co-authored 57 publications receiving 3766 citations. Previous affiliations of Pippa G. Al-Rawi include Medical Research Council.
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Journal ArticleDOI
Cerebral extracellular chemistry and outcome following traumatic brain injury: a microdialysis study of 223 patients
Ivan Timofeev,Keri L.H. Carpenter,Jurgens Nortje,Pippa G. Al-Rawi,M. T. O’Connell,Marek Czosnyka,Peter Smielewski,John D. Pickard,David K. Menon,Peter J. Kirkpatrick,Arun K. Gupta,Peter J. Hutchinson +11 more
TL;DR: The results of this study suggest that extracellular metabolic markers are independently associated with outcome following traumatic brain injury and whether treatment-related improvement in biochemistry translates into better outcome remains to be established.
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Evaluation of a Near-Infrared Spectrometer (NIRO 300) for the Detection of Intracranial Oxygenation Changes in the Adult Head
TL;DR: The NIRO 300 reflects changes in cerebral tissue oxygenation when TOI is calculated, with a high degree of sensitivity and specificity.
Journal ArticleDOI
Clinical cerebral microdialysis: a methodological study.
Peter J. Hutchinson,M. T. O’Connell,Pippa G. Al-Rawi,L. B. Maskell,Rupert Kett-White,Arun K. Gupta,Hugh K. Richards,D. B. A. Hutchinson,Peter J. Kirkpatrick,John D. Pickard +9 more
TL;DR: Variations in flow rate enabled the relative recovery to be calculated using a modification of the extrapolation-to-zero-flow method, and Glutamate results obtained with the enzyme analyzer showed good correlation with those from HPLC.
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Effect of cerebral perfusion pressure augmentation on regional oxygenation and metabolism after head injury.
Andrew J. Johnston,Luzius A. Steiner,Jonathan P. Coles,Doris A. Chatfield,Tim D. Fryer,Peter Smielewski,Peter J. Hutchinson,M. T. O’Connell,Pippa G. Al-Rawi,Franklin I. Aigbirihio,John C. Clark,John D. Pickard,Arun Kumar Gupta,David K. Menon +13 more
TL;DR: The results suggest that the ischemic level of brain tissue oxygen may lie at a level below 14 mm Hg (1.8 kPa); however, the data do not allow us to be more specific.
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Inflammation in human brain injury: intracerebral concentrations of IL-1alpha, IL-1beta, and their endogenous inhibitor IL-1ra.
Peter J. Hutchinson,M. T. O’Connell,Nancy J. Rothwell,Stephen J. Hopkins,Jurgens Nortje,Keri L.H. Carpenter,Ivan Timofeev,Pippa G. Al-Rawi,David K. Menon,John D. Pickard +9 more
TL;DR: Feelings of feasibility of the microdialysis methodology in recovering IL-1 family cytokines for assessing their inter-relationships in the injured human brain are demonstrated, and a neuroprotective role forIL-1ra is suggested.