J. Carlos Menéndez

TL;DR: In this paper, the influence of solvent polarity and pH on the native fluorescence properties of these alkaloids was studied, finding that in organic solvents or in aqueous solutions (pH 55-72) the neutral form of the luotonin derivatives emit in the region of 410-450 nm but, in both media, acidification to pH values below 30 causes a new emission band to appear at about 500 nm.

TL;DR: 1d was able to induce the NRF2 signature, promoting the expression of the antioxidant response enzymes HO-1 and NQO1, via a KEAP1-dependent mechanism, and shows the therapeutic potential of this compound, especially for ALS patients with a SOD1 mutation.

TL;DR: The reaction of 1-nitrobicyclo[n.1]alkane-(6 + n)ones with sodium borohydride followed by acidic workup led to ring opening via a one-pot sequence comprising the retro-Dieckmann-type opening of the α-nitroketone structural fragment, followed by aldehyde reduction and a final Nef reaction, leading to highly functionalized 12 to 14-membered carbocyclic ketones bearing three stereocent

TL;DR: A small library of A-and D-ring modified luotonin-inspired heterocyclic systems have been synthesised in moderate to good yields following a six-step route that starts from phenylalanine and has the final key stage an intramolecular Povarov reaction of imines obtained from a tetrahydroquinoline-derived alkynyl aldehyde and various arylamines as mentioned in this paper.