J
J. Carlos Menéndez
Researcher at Complutense University of Madrid
Publications - 336
Citations - 7983
J. Carlos Menéndez is an academic researcher from Complutense University of Madrid. The author has contributed to research in topics: Catalysis & Michael reaction. The author has an hindex of 37, co-authored 317 publications receiving 6784 citations. Previous affiliations of J. Carlos Menéndez include Université Paul Cézanne Aix-Marseille III & Universiti Sains Malaysia.
Papers
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Journal ArticleDOI
Antioxidants as Molecular Probes: Structurally Novel Dihydro-m-Terphenyls as Turn-On Fluorescence Chemodosimeters for Biologically Relevant Oxidants.
Víctor González-Ruiz,Jegathalaprathaban Rajesh,Ana I. Olives,Damiano Rocchi,Jorge Gómez-Carpintero,Juan Francisco González,Vellaisamy Sridharan,M. Antonia Martín,J. Carlos Menéndez +8 more
TL;DR: The mild reaction conditions and sensitive fluorescent response lead us to propose dihydroterphenyls with an embedded anthranilate moiety as chemosensors/chemodosimeters for ROS detection.
Journal ArticleDOI
A Facile Three-Component [3 + 2]-Cycloaddition/Annulation Domino Protocol for the Regio- and Diastereoselective Synthesis of Novel Penta- and Hexacyclic Cage Systems, Involving the Generation of Two Heterocyclic Rings and Five Contiguous Stereocenters.
Raju Suresh Kumar,Hasnah Osman,Subbu Perumal,J. Carlos Menéndez,Mohamed Ashraf Ali,Rusli Ismail,Tan Soo Choon +6 more
TL;DR: An expedient, three-component, [3+2]-cycloaddition/annulation domino protocol for the synthesis of a series of cage penta-and hexacyclic compounds in good to excellent yields is described in this article.
Journal ArticleDOI
Ionic Liquid Mediated Synthesis and in vitro Mechanistic Exploration of Polycyclic Cage‐like Heterocyclic Hybrid
Raju Suresh Kumar,Abdulrahman I. Almansour,Natarajan Arumugam,D. Kotresha,J. Carlos Menéndez,Raju Ranjith Kumar +5 more
Book ChapterDOI
Epigenetic Therapy of Cancer
TL;DR: The chapter discusses a promising class of epigenetic targets: the family members of the bromodomain and extra-terminal (BET) protein, most notably BRD4, which is directly implicated in the activation of oncogenes such as MYC, one of the most common overexpressed genes in many cancers.
Journal ArticleDOI
Mechanochemical Aza-Vinylogous Povarov Reactions for the Synthesis of Highly Functionalized 1,2,3,4-Tetrahydroquinolines and 1,2,3,4-Tetrahydro-1,5-Naphthyridines.
TL;DR: In this paper, the aza-vinylogous Povarov reaction between aromatic amines, α-ketoaldehydes or α-formylesters and α,β-unsaturated dimethylhydrazones was carried out in a sequential three-component fashion under mechanochemical conditions.