J. David Spence

TL;DR: In this trial, moderate reduction of total homocysteine after nondisabling cerebral infarction had no effect on vascular outcomes during the 2 years of follow-up, and the consistent findings of an association of totalhomocysteines with vascular risk suggests that further exploration of the hypothesis is warranted and longer trials in different populations with elevated total homocrysteine may be necessary.

TL;DR: Noninvasive ambulatory ECG monitoring for a target of 30 days significantly improved the detection of atrial fibrillation by a factor of more than five and nearly doubled the rate of anticoagulant treatment, as compared with the standard practice of short-duration ECG Monitoring.

TL;DR: Among patients with a PFO who had a cryptogenic stroke, the risk of subsequent ischemic stroke was lower among those assign to PFO closure combined with antiplatelet therapy than among those assigned to anti platelet therapy alone; however, PFOclosure was associated with higher rates of device complications and atrial fibrillation.

TL;DR: In vitro findings support the flavonoid, naringin, or the furanocoumarin, 6',7'-dihydroxybergamottin, as being active ingredients, but a recent investigation indicated that neither of these substances made a major contribution to grapefruit juice-drug interactions in humans.

TL;DR: Carotid plaque area and progression of plaque identified high-risk patients and may improve cost-effectiveness of secondary preventive treatment and may be useful for targeting preventive therapy.