Background
The nonselective 5-HT4 receptor agonists, cisapride and tegaserod have been associated with cardiovascular adverse events (AEs).

https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2036.2012.05011.x

Systematic review: cardiovascular safety profile of 5-HT(4) agonists developed for gastrointestinal disorders

Objective Recovery, defined as a personal process of living with mental illness, has become a prominent concept in mental health care. We aimed to map the state of the art of conceptualizing recovery, its promoting and impeding factors, recovery-oriented practice, and the assessment of recovery. Method A scoping review of systematic reviews and meta-analyses was performed. Systematic searches were conducted, supplemented with hand-searching in reference lists. Results Of 228 articles that were identified and 33 that were reviewed, a total of 25 were included. This review showed that the CHIME conceptual framework for personal recovery is widely endorsed, containing the elements of connectedness, hope and optimism, identity, meaning in life, and empowerment. Although personal recovery first and foremost starts from individual preferences, the CHIME framework should be adapted according to culture and unique population characteristics. "Difficulties and trauma" should be added, and the person's choice, risk taking, and coping with challenges should be emphasized. Barriers to recovery are stigma and negative effects of mental health services and medication. Facilitators of recovery include spirituality, personal agency, and social support. Recovery-focused interventions, in which peer providers are involved, enhance recovery, hope, and empowerment. For assessing recovery outcomes, multiple instruments are accepted as methodologically sound. Conclusions Personal recovery is conceptualized as complementary to clinical recovery and represents processes rather than outcomes. Additional work is needed to bridge the gap between the concept of recovery-oriented practice and routinely provided interventions. A broad framework of recovery is needed, and more research is needed into the working mechanisms of personal recovery processes. (PsycINFO Database Record (c) 2019 APA, all rights reserved).

Conceptualizations, assessments, and implications of personal recovery in mental illness: A scoping review of systematic reviews and meta-analyses.

In this paper, we describe the system architecture and prototype measurements of a MEMS gyroscope system with a resolution of 0.025deg/s/ radic(Hz). The architecture makes extensive use of control loops, which are mostly in the digital domain. For the primary mode both the amplitude and the resonance frequency are tracked and controlled. The secondary mode readout is based on unconstrained SigmaDelta force-feedback, which does not require a compensation filter in the loop and thus allows more beneficial quantization noise shaping than prior designs of the same order. Due to the force-feedback, the gyroscope has ample dynamic range to correct the quadrature error in the digital domain. The largely digital setup also gives a lot of flexibility in characterization and testing, where system identification techniques have been used to characterize the sensors. This way, a parasitic direct electrical coupling between actuation and readout of the mass-spring systems was estimated and corrected in the digital domain. Special care is also given to the capacitive readout circuit, which operates in continuous time.

/pdf/a-closed-loop-digitally-controlled-mems-gyroscope-with-1t16dkc5r2.pdf

A Closed-Loop Digitally Controlled MEMS Gyroscope With Unconstrained Sigma-Delta Force-Feedback

Chronic constipation is common among nursing home residents. The aim of this study was to evaluate safety, tolerability and pharmacokinetics of the selective 5HT(4) receptor agonist prucalopride in elderly, chronically constipated patients in nursing homes. A multicentre, phase II, randomized, double-blind dose-escalation study in 89 elderly constipated nursing home residents treated with placebo, 0.5, 1 or 2 mg prucalopride once daily for 28 days was analysed. Adverse events, vital signs, ECG, Holter monitor and pharmacokinetics were assessed (Clinicaltrials.gov identifier: NCT00627692). Patients' mean age was 83 years; 88% had a history of cardiovascular diseases. Most frequent adverse events, at least possibly related to prucalopride, were diarrhoea and abdominal pain. Relative to placebo, there were no differences in vital signs, ECG corrected QT interval, ECG morphology parameters, or incidence of supraventricular or ventricular arrhythmias on Holter monitoring. Plasma prucalopride concentrations increased proportionally with administered dose. Prucalopride up to 2 mg once daily for 4 weeks was safe and well-tolerated by constipated elderly patients, with no differences vs placebo in ECG or a range of Holter-monitoring parameters.

https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2982.2009.01398.x

Safety assessment of prucalopride in elderly patients with constipation: a double-blind, placebo-controlled study.

A calibration-free, high-resolution analog-to-digital converter designed for a bioluminescence sensor array employs incremental sigma-delta (ΣΔ) modulation to combine the advantages of oversampling with an input multiplexing capability. The resolution of incremental ΣΔ modulators can be improved significantly by means of a technique similar to extended counting. In the approach proposed in this paper, analog-to-digital conversion is accomplished with a two-step process in which the residual error from a second-order incremental ΣΔ modulator is encoded using a successive approximation ADC. By this means it is possible to achieve enhanced resolution and improved static linearity while maintaining a one-to-one mapping between individual input and output samples. An experimental implementation of the proposed modulator has been integrated in a 0.18-μm CMOS technology. Operating from a 1.8-V supply, it achieves a dynamic range of 90.1 dB and a peak signal-to-noise and distortion ratio (SNDR) of 86.3 dB at a conversion rate of 1 MSample/s, with 38.1-mW power consumption.

A High-Resolution Low-Power Incremental $\Sigma\Delta$ ADC With Extended Range for Biosensor Arrays

Extended-counting analog-to-digital conversion combines the accuracy of /spl Sigma//spl Delta/ modulation with the speed of algorithmic conversion. In this paper, a double-sampling technique is introduced for this type of converter. It is based on a variant of the fully floating bilinear integrator. This way, the clock frequency of the converter is almost halved. An experimental converter was designed in a 0.6-/spl mu/m CMOS technology for a bandwidth of 500 kHz at a 3.3-V supply. In the switched-capacitor implementation, the hardware is extensively reused. This way, the converter can be realized with only one operational amplifier. On the other hand, compared to alternative implementations, the amount of switches is increased. These are designed carefully in order not to degrade the performance. The converter converts a sample in 24 clock cycles and achieves a dynamic range of 87 dB. The peak signal-to-noise ratio (SNR) and signal-to-noise-plus-distortion ratio (SNDR) were measured to be 82 and 81 dB, respectively. The power consumption was 28-mW analog and 20-mW digital. The converter core occupies 0.7 mm/sup 2/ including digital logic.

A double-sampling extended-counting ADC

A Web-based system for training electric circuit analysis is presented in this paper. It is centered on symbolic analysis techniques and it not only verifies the student's final answer, but it also tracks and coaches him/her through all steps of his/her reasoning path. The system mimics homework assignments, enhanced by immediate personalized feedback. Evaluation data based upon a first trial indicate that this tool is a useful complement to the traditional training approach.

/pdf/web-based-trainer-for-electrical-circuit-analysis-2v8h3paoxz.pdf

Web-Based Trainer for Electrical Circuit Analysis

One of the most interesting properties of continuous time /spl Sigma//spl Delta/ modulators is their implicit anti-aliasing filter. Unfortunately, peaking in their signal transfer function (STF) demands a 'no-overload' filter to precede the modulator. A technique and two new topologies, which can achieve an almost flat STF, are proposed. Meanwhile, the topologies still have the desired feature that the internal nodes contain few input related signals.

Controlled behaviour of STF in CT ΣΔ modulators

Objectives: In recent years, the concept of recovery has gained ground in the treatment of persons with dual diagnosis. Recovery refers to living a meaningful life despite limitations caused by men...

The concept of recovery as experienced by persons with dual diagnosis : a systematic review on qualitative research from a first-person perspective

This paper presents a high-order double-sampling single-loop /spl Sigma//spl Delta/ modulation analog-to-digital (A/D) converter. The important problem of noise folding in double-sampling circuits is solved here at the architectural level by placing one of the zeros in the modulator's noise transfer function at half the sampling frequency instead of in the baseband. The resulting modulator is of fifth order but has the baseband performance of a fourth-order modulator. Through the use of an efficient switched-capacitor implementation, the overall circuit uses only four operational amplifiers and hence, its complexity is similar to that of a fourth-order modulator. An experimental 1-bit modulator was designed for an oversampling ratio of 96 and a bandwidth of 250 kHz at a 3.3-V supply in a conservative 0.8-/spl mu/m standard CMOS process. Due to the double-sampling, the sampling frequency is 48 MHz, although the circuits operate at a clock frequency of only 24 MHz. The circuit achieves a dynamic range of 94 dB. The peak signal-to-noise ratio and signal-to-noise-plus-distortion ratio were measured to be 90 and 86 dB, respectively. The power consumption of the complete circuit including clock drivers and output pad drivers was 43 mW. The analog blocks (opamps, comparators, etc.) consume 30 mW of this total.

J. De Maeyer

Papers

A double-sampling extended-counting ADC

Web-Based Trainer for Electrical Circuit Analysis

Controlled behaviour of STF in CT ΣΔ modulators

The concept of recovery as experienced by persons with dual diagnosis : a systematic review on qualitative research from a first-person perspective

A 250-kHz 94-dB double-sampling /spl Sigma//spl Delta/ modulation A/D converter with a modified noise transfer function