J.-M. Tiercy

TL;DR: It is shown that a high degree of HLA compatibility is associated with increased patient survival and higher requirements for HLA matching decrease the number of available donors, but even when requirements for compatibility are high, the chances of finding a donor remain considerable.

TL;DR: This update is an extract of the main report that documents the additions and revisions to the nomenclature of human leukocyte antigen (HLA) specificities following the principles established in previous reports.

TL;DR: In multivariate analyses, HLA compatibility was the variable most significantly associated with survival and treatment-related mortality and best results for transplants from 10/10 matched donors were found.

TL;DR: In spite of their lower expression, HLA-C antigens still represent relevant transplantation barriers that should be considered when searching for an unrelated donor.

TL;DR: The presence of such a high number of histoincompatibilities in a group of relatively well matched D/R pairs will severely hinder the analysis of the role of HLA in marrow transplantation and that conclusions from studies in which D/ R pairs are matched by conventional typing must be interpreted with extreme caution.