J. Morgan Freiman

TL;DR: Testing for hepatitis C virus core antigen (HCVcAg) is a potential replacement for NAT and could be attractive as a single-step diagnosis for chronic HCV infection in high-prevalence settings, which would streamline the HCV cascade of care and reduce loss to follow-up.

TL;DR: A systematic review of 44 studies evaluat... as discussed by the authors showed that diagnosis of chronic hepatitis C virus (HCV) infection usually requires both a positive HCV antibody screen and confirmatory nucleic acid testing (NAT).

TL;DR: Although most HIV-infected patients were screened for prevalent HCV infection at enrollment in care, only half who were HCV uninfected were screened again, and screening varied between sites, even when controlling for demographics and risk behaviors.

TL;DR: The target limit of detection (LOD) necessary to diagnose the majority of people with HCV eligible for treatment was determined, and characteristics associated with low-level viraemia (LLV) (defined as the lowest 3% of the distribution of HCV RNA) were identified to understand those at risk of being misdiagnosed.